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NaNO2/Na2S2O8介导烯烃硝芳化反应合成硝基异喹啉二酮研究

本站小编 Free考研考试/2022-02-14

摘要/Abstract



报道了一种利用N-丙烯酰基-N-甲基芳甲酰胺的自由基硝芳化合成硝基异喹啉二酮的新方法. 该方法以廉价易得的NaNO2/Na2S2O8为硝基自由基来源. 实验表明18-crown-6可以促进反应的进行. 与现有方法相比, 该方法可避免有毒NO2气体的使用, 具有环境友好、实验操作简便等优点.
关键词: 烯烃, 硝芳化, 环化, 硝基自由基, 异喹啉二酮
A new method for the synthesis of nitro-functionalized isoquinolinediones by arylnitration of methacryloylbenzamides has been reported. Readily accessible NaNO2/Na2S2O8 was used as nitro radical precursor, and 18-crown-6 was used to promote the reaction. Compared with the existing method, this method is not only environmentally friendly but also easy to operate.
Key words: Keywords alkenes, arylnitration, cyclization, nitro radical, isoquinolinediones


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