摘要/Abstract

二氟甲基化反应经过近二十年的发展已取得了较为显著的研究成果. 除直接和间接二氟甲基化反应外, 二氟甲基砌块参与的化学转化是一种向有机化合物中引入二氟甲基的新策略. 相比于亲电、亲核和自由基二氟甲基化试剂, 二氟甲基砌块的种类仍然有限并有待进一步开发. 其中, 二氟甲基重氮甲烷是近年来发展的一类新型含氟砌块, 受到了研究****们的高度关注. 综述了二氟甲基重氮甲烷及其稳定替代物的最新应用研究进展, 着重介绍了其反应类型及相关机理, 并对今后的发展方向进行了展望.
关键词: 二氟甲基重氮甲烷, 二氟甲基化, 含氟砌块, 吡唑
Difluoromethylation has achieved remarkable progress in the past two decades. In addition to the direct difluoromethylation and the stepwise difluoromethylation, chemical transformation starting from CF₂H-containing building blocks is a novel strategy to introduce difluoromethyl group into organic compounds. Compared with electrophilic-, nucleo- philic- and free radical-difluoromethylation reagents, the types of CF₂H-containing building blocks are still limited and less explored. Among them, difluoromethyl diazomethane (CF₂HCHN₂) is a new type of fluorine-containing building block developed in recent years, which has received much attention from researchers. The recent progress in the application of difluoromethyl diazomethane and its surrogates as fluorine-containing building blocks is summarized, focusing on the reaction types and related mechanisms, and the developmental direction in the future is prospected.
Key words: difluoromethyl diazomethane, difluoromethylation, fluorinated building block, pyrazole


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