摘要/Abstract

有机物的卤化反应是有机合成中最重要的转化之一. 传统釜式卤化反应存在高放热及选择性差等问题, 且卤化试剂一般具有毒性和腐蚀性. 流动化学在传质和传热方面具有显著优势, 可精确控制反应温度及试剂用量, 并且可在线淬灭危险试剂, 避免其暴露. 按有机化合物卤化反应分类, 系统地归纳了流动化学在氟化反应、氯化反应、溴化反应和碘化反应中的应用进展, 并展望了其发展趋势.
关键词: 流动化学, 微反应器, 连续流, 卤化, 有机合成
The halogenation of organic compounds is one of the most important transformations in organic synthesis. However, there are some problems in traditional batch halogenation, such as high exothermicity, poor selectivity and the use of highly toxic and corrosive halogenating agents. Flow chemistry has its unique advantages such as high mixing efficiency, fast heat and mass transfer performance, accurate control over process parameters and enhanced process safety, reduced energy input and so on. According to the classification of halogenation of organic compounds, the main progress of flow chemistry in fluorination, chlorination, bromination and iodization is summarized systematically, and its development trend is prospected.
Key words: flow chemistry, microreactor, continuous flow, halogenation, organic synthesis


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