摘要/Abstract
钯催化的有机转化反应是金属有机化学的一个重要分支.由于其可以高效构建碳-碳键和碳-杂键，钯催化在合成化学、材料科学和医药工业等领域具有广泛应用，但其中部分反应存在条件苛刻（如需要高温、使用强碱）等不足.另一方面，可见光催化反应利用可见光作为能量来源，通过产生高活性的反应中间体，在温和条件下实现了许多常规热反应条件下不能实现的化学转化，但也存在反应类型和底物范围有限等问题.针对这两个领域各自存在的问题，人们通过结合可见光催化和钯催化，利用光敏剂与有机钯络合物之间的电子转移或能量转移，在温和条件下高效高选择性地实现了一系列新颖的有机转化，具有广谱的底物适用范围和良好的应用前景.在这些转化中，可见光催化与钯催化既各司其职，又相互协作，缺一不可.以不同反应类型为主线，总结了近年来可见光和钯协同催化的有机合成化学研究进展，并分析了该领域未来的重点研究方向.
关键词: 可见光催化, 钯催化, 协同催化, 有机合成
Palladium-catalyzed organic transformations is an important branch of organometallic chemistry. Because it can efficiently construct carbon-carbon bonds and carbon-heteroatom bonds, palladium catalysis has been widely used in synthetic chemistry, material science and pharmaceutical industry. However, some of these reactions suffer from harsh reaction conditions, including high temperature and strong base. On the other hand, the visible-light photoredox catalysis employs the visible light as the energy source to generate highly reactive intermediates and realize many novel transformations, which are rare under the normal thermal reaction conditions, under mild reaction conditions. However, there are also limitations in reaction types and substrate scope in this field. In order to solve such problems in these two fields, organic chemists have merged the visible-light photoredox catalysis and palladium catalysis, realizing a series of novel organic transformations through the electron transfer or energy transfer between photosensitizer and organic palladium complex under mild conditions with high efficiency and selectivity, which has broad substrate scope and great application potential. In these transformations, visible-light photoredox catalysis and palladium catalysis both play their respective roles and cooperate well. The application of visible light photoredox and palladium dual catalysis in organic synthesis is summarized and the future research directions in this field are analyzed, which might help the further development of this field.
Key words: visible-light photoredox catalysis, palladium catalysis, dual catalysis, organic synthesis
PDF全文下载地址:
点我下载PDF
