摘要/Abstract
针对以硫单质为硫源的吲哚环中C—S键构筑中催化剂无法回收的问题，制备了2-吡啶甲酸改性壳聚糖（PACS）负载不同类型铜的催化剂，用于催化吲哚、硫粉和碘苯三组分反应一锅法制备C-3位硫醚基吲哚，反应收率高达92%，底物适用性良好.对催化效果最佳的催化剂（PACS@Cu（OAc）2）进行了热重分析（TGA）、扫描电子显微镜（SEM）、X射线光电子能谱（XPS）等表征与分析，结果表明该催化剂具有不需额外添加配体、易于分离回收及可重复使用的优点.
关键词: 壳聚糖, 吲哚, 硫粉, 催化, 非均相
Aiming at the problem that the catalyst can not be recovered during the construction of the C-S bond in the indole ring with sulfur powder as the sulfur source, 2-pyridinecarboxylic acid modified chitosan (PACS) catalyst with different type of copper was prepared, which was used to catalyze the three-component reaction of indole, sulfur powder and iodobenzene to prepare C-3 thioether-based indole in a one-pot method. The reaction yield is as high as 92%, and the substrate has good applicability. The most suitable catalyst[PACS@Cu(OAc)2] was characterized and analyzed by thermogravimetric analysis (TGA), scanning electron microscope(SEM), X-ray photoelectron spectroscopy(XPS), etc. It shows that the catalyst has the advantages of no additional ligand, easy separation and reusable.
Key words: chitosan, indole, sulfur powder, catalyze, heterogeneous
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