摘要/Abstract

通过双官能团硫脲催化的吲哚-3-酮对不饱和酮酯的不对称Michael加成反应研究，以很高的产率、很好的对映选择性和非常好的非对映选择性得到了手性的2-取代吲哚-3-酮类化合物，对吲哚类化合物的手性合成具有积极意义.
关键词: 不对称催化, 双官能团硫脲, Michael加成, 吲哚-3-酮, 不饱和酮酯
The asymmetric Michael addition of 1-acetylindolin-3-ones to β,γ-unsaturated α-keto esters catalyzed by bifunctional thioureas has been developed. Enantio-pure 2-substituted indolin-3-one derivatives were obtained easily in excellent yields (up to 99%) with good diastereoselectivity (up to 10:1) and excellent enantioselectivities (up to 99.5%), which would be useful for the chiral synthesis of indole-related compounds.
Key words: asymmetric catalysis, bifunctional thiourea, Michael addition, 1-acetylindolin-3-one, β,γ-unsaturated α-keto ester


PDF全文下载地址:

点我下载PDF