摘要/Abstract
香豆素和噻唑是两类具有广泛的生物活性和药理作用的杂环化合物，合成含噻唑基的香豆素衍生物在药物化学上具有重要的意义.本研究发展了一种方便高效地通过3-乙酰基香豆素和硫脲/N-取代硫脲在I2/CuO催化作用下一锅反应合成3-（2-氨基）-4-噻唑基）香豆素衍生物的方法.所有目标化合物通过核磁共振、红外光谱、质谱分析证实.
关键词: 香豆素, 2-氨基噻唑, 一锅反应, I2/CuO
Coumarin and thiazole are two classes of important heterocycles with many biological activities and pharmacological effects. It is very meaningful to synthesize thiazolyl coumarin derivatives in medicinal chemistry area. In this study, a facile and efficient one-pot process was developed to synthesize substituted aminothiazoles from 3-acetylcoumarins and thiourea/N-substituted thioureas under the media of I2/CuO. All target molecules were characterized by NMR, IR spectra and MS.
Key words: coumarin, 2-aminothiazole, one-pot reaction, I2/CuO
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