摘要/Abstract

报道了利用廉价易得的二甲基亚砜作为甲硫基源，实现8-氨基喹啉导向的芳基酰胺的二甲硫基化反应.利用CuSO₄·5H₂O作为促进剂，以中等到较好的收率高效地合成了一系列含有二甲硫基的芳酰胺衍生物.此外，该反应体系具有反应条件温和、不需要外加其它氧化剂的特点.
关键词: 二甲硫基化, 二甲基亚砜, 8-氨基喹啉, Cu促进
Cu(II)-promoted dimethylthiolation of C(sp²)-H bonds using DMSO as the methylthiolation source with the assistance of an 8-aminoquinoline directing group have been developed. A number of dimethylthiolated benzamides were efficiently synthesized using CuSO₄·5H₂O as a promoter in moderate to good yields. In addition, this reaction system features facile conditions and no other oxidant additive was required.
Key words: Dimethylthiolation, DMSO, 8-Aminoquinoline, Copper-promoted


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