摘要/Abstract

报道了一种用高价碘试剂促进缩氨基硫脲分子内氧化偶联反应，能够有效地合成2-氨基-1，3，4-噻二唑类衍生物.高价碘可以作为温和的反应试剂，拥有毒性低、廉价可循环易操作的特性.该反应具有原料易制得、操作简便以及较好的底物适用性等特点.反应机理也进行了初步研究.
关键词: 高价碘, 氧化, 芳香醛, 噻二唑
A highly method for intramolecular oxidative coupling reaction of thiosemicarbazone promoted by hypervalent iodine reagent was reported. 2-Amino-1,3,4-thiadiazole derivatives could be synthesized effectively. Hypervalent iodine could be used as a mild reagent with low toxicity, low cost, easy circulation and operation. The reaction had the advantages of easy preparation of raw materials, simple operation and better performance. The applicability of substrates and the reaction mechanism were also preliminarily studied.
Key words: hypervalent iodine, oxidation, aromatic aldehydes, thiadiazole


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