摘要/Abstract

发展了一种4-二甲氨基吡啶（DMAP）促进的高立体选择性合成多取代螺环丙烷吡唑啉酮的方法.该反应以吡唑啉酮、芳醛和溴乙酸酯为原料，DMAP作为碱，经三组分一锅反应，合成一系列收率高且非对映选择性好的目标化合物.该反应具有操作简单、产率高以及非对映选择性好等优点.该合成方法对于螺环丙烷的研究具有重要的价值.
关键词: 一锅法合成, 多组分反应, 螺环丙烷, 吡唑酮, 4-二甲氨基吡啶(DMAP)
A 4-dimethylaminopyridine (DMAP)-promoted high stereoselectivity method for the synthesis of polysubstituted spiropropane pyrazolone was developed. A series of target compounds were synthesized from using pyrazolone, aromatic aldehyde and bromoacetate as raw materials, and DMAP as a base with high yield via three-component one-pot reaction. This reaction has the advantages of simple operation, high yield and good diastereotopic selectivity. In addition, this synthetic method is of great value for the study of spiropropane.
Key words: one-pot synthesis, multicomponent reactions, spirocyclopropane, pyrazolones, 4-dimethylaminopyridine (DMAP)


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