摘要/Abstract

有机硅化合物因其特殊的性质广泛应用于合成化学、医药、农药和材料等领域.有机硅化合物通常由亲核取代、烯烃硅氢化和碳氢键直接硅化等方法制备.近年来，交叉偶联构建碳硅键，特别是构建C（sp³）-Si键取得突破性进展，引起广泛关注和兴趣，成为有机硅化合物合成研究热点.从极性反转的硅亲核试剂即有机硅金属试剂角度，总结近些年来有机硅金属试剂参与交叉偶联合成有机硅烷研究进展.有机硅硼试剂、有机硅镁试剂、有机硅锌试剂、联硅试剂、有机硅铝试剂和有机硅锂试剂等六方面总结各类金属试剂在碳硅键偶联的进展.
关键词: 有机硅金属试剂, 交叉偶联, 过渡金属催化, 有机硅化合物
Organosilanes have been widely applied in synthetic chemistry, pharmaceuticals, agrochemicals, and materials due to the special properties. Several synthetic strategies including nucleophilic substitution, hydrosilylation of alkene, and C-H silylation have been developed. In recent years, significant progress has advanced in the cross-coupling of C-Si bond for the synthesis of organosilanes, especially in the break-through of the cross-coupling of C(sp³)-Si bond. It has become one of the hottest issues in synthetic chemistry. The recent progress on the cross-coupling of C-Si bond by using silyl reagents is summarized. The application of silyl reagents in cross-coupling for C-Si bond formation including silyl boranes, organosilyl magnesium, organosilyl zinc, unasymetric disilanes, organosilyl aluminum and organosilyl lithium reagents is mainly discussed.
Key words: silyl reagents, cross-coupling, transition-metal catalysis, organosilanes


PDF全文下载地址:

点我下载PDF