摘要/Abstract
以5.0 mol% NiCl2(dppe)作为催化剂, 催化(Z)-1,2-二芳硫基-1,2-二芳基烯烃和格氏试剂偶联反应, 高选择性制备了一系列多取代烯烃化合物. 有机硫基团经水解、氧化后生成二芳基二硫醚, 实现了硫资源的循环利用, 符合绿色化学要求. 同时, 此方法对不同取代的(Z)-1,2-二芳硫基-1,2-二芳基烯烃和格氏试剂均具有较好的适用性, 以较高的产率获得相应的目标产物, 为多取代烯烃的制备提供了有效的路径.
关键词: 镍催化偶联反应, 多取代烯烃, (Z)-1,2-二芳硫基-1,2-二芳基烯烃, 格氏试剂
A convenient protocol for the synthesis of multi-substituted alkenes from (Z)-1,2-diarylthio-1,2-diarylalkenes with Grignard reagents was developed via the highly selective coupling of (Z)-1,2-diarylthio-1,2-diarylalkenes catalyzed by 5.0 mol% NiCl2(dppe). The leaving organosulfur group could be converted to diaryldisulfide after hydrolysis and oxidation, which realized the recycling of sulfur resources, meeting the requirements of green chemistry. This process tolerated to different (Z)-1,2-diarylthio-1,2-diarylalkenes and Grignard reagents to deliver products in good to excellent yields, providing an efficient route to multi-substituted alkenes.
Key words: nickel-catalyzed coupling, multi-substituted alkenes, (Z)-1,2-diarylthio-1,2-diarylalkenes, Grignard reagents
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