摘要/Abstract
三芳基膦化合物在医药合成、过渡金属催化等方面扮演十分重要的角色. 报道了碱促进的芳基卤代物与烷基取代的二芳基膦的C(sp 2)—P键偶联新方法合成三芳基膦. 该方法具有无过渡金属催化剂参与、反应底物来源广泛、后处理简洁等优点.
关键词: 无过渡金属, 烷基取代的二芳基膦, 芳基卤代物, 三芳基膦化合物
Triarylphosphines play an important role in pharmaceutical synthesis and transition-meal-catalyzed reactions. In this paper, a novel method for the synthesis of triarylphosphines via base-promoted C(sp 2)—P cross-coupling reactions of alkyldiphenylphosphines with aryl halides is described. The transition-metal-free reaction condition, readily available starting materials and experimental simplicity are the features of the novel method.
Key words: transition metal-free, alkyldiphenylphosphines, aryl halides, triarylphosphines
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