摘要/Abstract

2，3-二氢喹唑啉-4（1H）-酮是一类重要的含氮稠杂环化合物，具有广泛的药理及生物活性，在药物合成与研发领域有着重要应用价值，因而其合成方法也倍受人们关注.归纳总结了2，3-二氢喹唑啉-4（1H）-酮类化合物的合成研究进展，主要介绍了以邻氨基苯甲酰胺、靛红酸酐、邻硝基苯甲酰胺、邻叠氮基苯甲酰胺、邻溴苯甲酰胺、邻溴苯甲腈、邻氨基苯甲酸、邻氨基苯甲腈、邻氨基N-甲基-N-丙二烯基苯甲酰胺、N-烷基苯胺等为起始原料的2，3-二氢喹唑啉-4（1H）-酮类化合物的合成研究进展概况及其反应机理.最后对该类化合物的合成研究进展进行了总结，并对其发展前景进行了展望.
关键词: 2,3-二氢喹唑啉-4(1H)-酮, 邻氨基苯甲酰胺, 靛红酸酐, N-烷基苯胺, C-H活化功能化, 钯催化
2,3-Dihydroquinazolin-4(1H)-one compounds are an important class of nitrogen-containing fused heterocycles, which possess a wide range of pharmacological and biological activities and have important applications in the fields of synthesis and research & development of drugs. Therefore, its synthetic methods have also attracted considerable attention. In this paper, the main advances in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their proposed reaction mechanisms from the raw materials such as o-aminobenzamides, isatoic anhydrides, o-nitrobenzamides, o-azidobenzamide, o-bromo-benzamide, o-bromobenzonitrile, o-aminobenzoic acids, o-aminobenzonitrile, o-amino-N-(propa-1,2-dienyl)benzamides, and N-alkyl anilines were introduced and reviewed, respectively. Finally, the synthesis of these compounds was summarized and the prospect of their development was prospected.
Key words: 2,3-dihydroquinazolin-4(1H)-one, o-aminobenzamides, isatoic anhydrides, N-alkyl anilines, C-H activation &, functionalization, palladium catalysis


PDF全文下载地址:

点我下载PDF