摘要/Abstract

报道了1，4-二氮杂双环[2.2.2]辛烷（DABCO）催化下的三组分一锅法合成双环邻-氨基腈衍生物，在该催化体系下，21种双环邻-氨基腈衍生物以68%~96%的收率制备得到.该方法于室温下即可顺利完成，反应时间短，目标化合物产率高.重要的是目标产物通过简单的过滤和乙醇洗涤即可获得
关键词: 1,4-二氮杂双环[2.2.2]辛烷(DABCO), 多组分反应, 邻-氨基腈衍生物, 环境友好, 乙醇
One-pot three-component reactions catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) for the synthesis of bicyclic ortho-aminocarbonitrile derivatives (21 examples, 68%~96%) have been developed. The reactions proceeded smoothly at room temperature and generated the corresponding products in short reaction time with high to excellent yields. Importantly, the desired products could be easily collected through simple filtration and washing with ethanol.
Key words: 1,4-diazabicyclo[2.2.2]octane (DABCO), multicomponent reaction, ortho-aminocarbonitrile derivatives, environmentally benign, ethanol


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