摘要/Abstract

报道了一种铜催化的1-芳基-1-环醇和1，3-二羰基化合物的环化反应，以中等到优秀的产率合成了一系列环烷烃稠合的二氢呋喃衍生物.该反应条件温和，官能团兼容性好.机理研究表明此环合反应可能经历了自由基中间体.
关键词: 环化反应, 环醇, 1,3-二羰基化合物, 二氢呋喃
A novel method of copper-catalyzed cyclization of 1-aryl-1-cycloalcohols and 1,3-dicarbonyl compounds has been developed, affording various cycloalkane-fused dihydrofurans in moderate to excellent yields. This transformation proceeds under mild conditions and with a good tolerance of functional groups. The mechanistic investigation revealed that the reaction involved radical intermediates.
Key words: cyclization, cycloalcohol, 1,3-dicarbonyl compound, dihydrofuran


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