摘要/Abstract

吡唑作为一种五元含氮杂环类化合物，不仅具有抗菌、抗肿瘤和抗氧化等生物活性，而且是一种重要的有机合成中间体，对其进行合成研究具有重要意义.以醛和肼作为腙的反应前体，研究了氯胺-T促进的醛、肼与富马酸酯的
[3+2]环加成反应，对反应条件进行了优化，合成了四取代吡唑类化合物，收率在60%～87%之间，其结构经¹H NMR、¹³C NMR、IR、HRMS等进行了确证.
关键词: 醛, 肼, 富马酸酯, 氯胺-T, 吡唑
Pyrazoles, a class of five-membered nitrogen-containing heterocyclic compounds, showed antibacterial, anticancer and antioxidative activity, and so on. They also served as important intermediates in organic synthesis. To develop the general and straightforward methods to their synthesis is of great significance. In this paper, a series of tetra-substituted pyrazoles were synthesized from aldehydes, hydrazines and fumarate esters by three-component[3+2] cycloaddition reaction in the presence of chloroamine-T with 60%~87% yields. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS analysis.
Key words: aldehyde, aldehyde, fumarate ester, chloroamine-T, pyrazole


PDF全文下载地址:

点我下载PDF