摘要/Abstract

为发现具有较高杀虫活性的先导化合物，结合本课题组前期研究结果，设计合成了系列含肟醚的松油烯-4-醇衍生物，并测试了杀虫活性.结果表明，目标化合物对粘虫具有较好的触杀作用，其中化合物2-甲基-5-异丙烯基-2-环己烯-1-酮肟-O-炔丙基醚（3a）的LD₅₀值为0.0054 mg/头，毒力是松油烯-4-醇的19.1倍，可以作为农药先导化合物进一步优化研究.
关键词: 肟醚, 松油烯-4-醇, 天然产物, 生物活性, 粘虫
In order to discover high activity lead compound, based on our previous studies, a series of terpinen-4-ol deri- vatives containing oxime ether were designed and synthesized. The bioassay results showed that the target compounds displayed good insecticidal activity against Mythimna separata (Walker). Especially, compound 3a exhibited satisfied activity with the LD₅₀ value of 0.0054 mg/insect, which is 19.1 times than terpinen-4-ol. As a high activity compound with simple structure, 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one O-prop-2-yn-1-yl oxime (3a) could be a lead compound for further study.
Key words: oxime ether, terpinen-4-ol, natural product, biological activity, Mythimna separata


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