摘要/Abstract

在固体酸性离子交换树脂Amberlyst-15的催化作用下，以乙醇作为溶剂，以芳香醛、β-酮酸酯、3-氨基-1，2，4-三唑或者2-氨基苯并咪唑为原料经过三组分一锅法反应合成了一系列三唑并[1，5-a]嘧啶衍生物5a～5m及二氢苯并[4，5]咪唑并[1，2-a]嘧啶类衍生物6a～6g.该方法简单高效、具有反应时间短、后处理简单、底物适用范围较广以及催化剂可以循环利用4次催化活性无明显下降的优点，符合绿色化学的基本标准.
关键词: 二氢嘧啶衍生物, 固体酸性离子交换树脂Amberlyst-15, 一锅法反应
Under the catalysis of solid acidic ion exchange resin Amberlyst-15, using ethanol as solvent, aromatic aldehyde, β-ketoester, and 3-amino-1,2,4-triazole or 2-aminobenzo as starting materials, a series of triazolo[1,5-a]pyrimidine derivatives 5a~5m and dihydrobenzo[4,5]imidazo[1,2-a]pyrimidines 6a~6g were synthesized by three-component one-pot reaction of imidazole derivatives. The method is simple and efficient, and has short reaction time, simple post-treatment and wide application range of the substrate. The catalyst can be recycled for 4 times without the significant decrease of catalytic activity. It conforms to the basic standard of green chemistry.
Key words: dihydropyrimidine derivative, solid acidic ion exchange resin Amberlyst-15, one-pot reaction


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