摘要/Abstract

八元环醚化合物在天然产物和生物活性分子中广泛存在，实现该类化合物的高效合成一直是有机化学家的关注热点.与五至七元环化合物合成方法相比，八元环醚化合物的合成更具挑战性.综述了近年来利用过渡金属催化法、环扩张法、Claisen重排法、烯烃复分解关环法，分子内酰胺烯醇烷基化法以及有机小分子催化串联环化法合成八元环醚类化合物的研究进展.
关键词: 八元环醚化合物, 合成方法, 不对称合成
Eight membered cyclic ether compounds are common structural motifs in natural products and bioactive molecules. The efficient synthesis of eight membered ethers has attracted wide attention for organic chemists. Compared with five-to seven-membered cyclic ethers, the synthesis of eight membered cyclic ethers is more challenging. In this paper, the synthetic methods for eight membered cyclic ethers by transition metal catalysis, ring expansion, retro-Claisen rearrangement, ring-closing metathesis, intramolecular amide enol alkylation and organic catalyzed tandem cyclization are reviewed.
Key words: eight-membered cyclic ethers, synthesis method, asymmetric synthesis


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