摘要/Abstract

以5，5-二甲氧基-2，4-二氧代戊酸乙酯为原料，设计合成了一系列含芳基异噁唑啉结构的吡唑-5-甲酰胺类化合物，产物结构经¹H NMR，¹³C NMR和HRMS确认.初步杀虫活性测试表明，多数化合物在500 mg/L浓度下对粘虫（Mythimna separate）有着较高的活性（致死率≥ 80%），在100 mg/L的浓度下，有三种化合物对粘虫仍有中等程度的活性（致死率≥ 60%）.在500 mg/L时，有四种化合物对苜蓿蚜（Aphis craccivora）也有较好的活性（致死率≥ 80%）.因此，对该类化合物的结构优化可作为寻求新型杀虫剂而进行深入研究.
关键词: 芳基异噁唑啉, 吡唑-5-甲酰胺, 合成, 杀虫活性
A series of 3-arylisoxazoline-pyrazole-5-carboxamide derivatives derived from ethyl 5,5-dimethoxy-2,4-dioxopentanoate were designed, synthesized, and characterized by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay indicated that most title compounds exhibited positive potency against Mythimna separate (Walker) at 500 mg/L. At the concentration of 100 mg/L, three compounds were still moderately active against Mythimna separate (Walker) (lethal rate≈60%). At 500 mg/L, four compounds were also active against Aphis craccivora. The results indicated that the potential of these 3-arylisoxazoline-pyrazole-5-carboxamide derivatives can be utilized in insecticide research with further optimization.
Key words: arylisoxazoline, pyrazole-5-carboxamide, synthesis, insecticidal activity


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