摘要/Abstract
通过硅胶和MCI柱色谱以及制备液相色谱等分离方法从金钗石斛中分离得到3个联苄基类衍生物，其中化合物1为外消旋的双联苄基衍生物，进一步通过手性拆分得到一对对映异构体1a和1b，通过计算所得的电子圆二色谱（ECD）谱图与实测的ECD谱图进行比较得出1a和1b的绝对构型.经高分辨质谱和核磁共振等波谱技术确立化合物1~3的结构分别为二聚体石斛素A（1）、金钗石斛素B（2）和金钗石斛素C（3）.
关键词: 金钗石斛, 兰科, 联苄基衍生物, 金钗石斛素
By silica gel, MCI column chromatographic and preparative high performance liquid chromatography (HPLC) technologies, three new bibenzyl derivatives were isolated from the tubes of Dendrobium nobile. One racemic compound was further purified by chiral (HPLC) to obtain a pair of enantiomers 1a and 1b, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. By using spectroscopic techniques including NMR and HR-ESIMS, the structures of compounds 1~3 were identified as didendronbiline A (1), dendronbiline B (2), and dendronbiline C(3).
Key words: dendrobium nobile, orchidaceae, bisbibenzyl, dendronbiline
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