摘要/Abstract

在氯化胆碱和氯化锌组成的深共融溶剂中，以2-氨基苯乙酮和芳香炔烃为原料，通过环化偶联反应，合成了一系列2，4-二取代喹啉衍生物；当n（氯化胆碱）：n（氯化锌）=1：2，反应温度为80℃时，反应3 h即获得高达98%的产率.该方法无需额外添加催化剂，而且反应条件温和、操作简单、底物范围较广泛.
关键词: 深共融溶剂, 氯化胆碱, 氯化锌, 环化偶联, 2,4-二取代喹啉
In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2,4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1:2, the yield up to 98% was achieved at 80℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates.
Key words: deep eutectic solvent, choline chloride, zinc chloride, cyclization coupling, 2,4-disubstituted quinoline


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