摘要/Abstract

为了寻找具有较好生物活性的吡唑肟醚类衍生物，基于唑螨酯的结构，在吡唑环的4-位引入1，3，4-噁二唑结构，设计合成了15个结构新颖的吡唑肟醚类化合物，它们的结构通过¹H NMR、¹³C NMR、元素分析等手段得到表征.生测研究表明，部分目标化合物在500和100μg/mL浓度下对粘虫（Oriental armyworm）或蚜虫（Aphis medicaginis）都有较好的杀虫效果，其中10a，10e，10f和10j在100 μg/mL时对粘虫有100%的杀死率，10g，10j和10l在100 μg/mL时对蚜虫有100%的杀虫活性.另外，10l在500 μg/mL浓度下对朱砂叶螨（Tetranychus cinnabarinus）也具有100%的杀灭效果.
关键词: 1,3,4-噁二唑, 吡唑肟醚, 合成, 杀虫活性
In search of novel pyrazole oxime ether derivatives with potent bioactivities, fifteen new pyrazole oxime ethers were designed and synthesized by introducing 1,3,4-oxadiazole moiety into the C-4 position of pyrazole based on the structure of fenpyroximate. Their structures were confirmed by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data showed that some title compounds possessed good insecticidal activities against Oriental armyworm or Aphis medicaginis at the concentration of 500 and 100 μg/mL. At 100 μg/mL, compounds 10a, 10e, 10f and 10j displayed 100% mortality rate against Oriental armyworm, and compounds 10g, 10j and 10l showed insecticidal activity against Aphis medicaginis with 100%. In addition, compound 10l had 100% mortality rate against Tetranychus cinnabarinus at 500 μg/mL.
Key words: 1,3,4-oxadiazole, pyrazole oxime ether, synthesis, insecticidal activity


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