摘要/Abstract
研究了苄基异喹啉生物碱的一条新的通用合成路线.其关键步骤为1-苄基-3，4-二氢异喹啉的铜催化氧化芳构化串联反应.以胡椒醛或3，4-二甲氧基苯甲醛为起始原料，经8步反应，分别以42%、37%和37%的总收率实现了三个苄基异喹啉生物碱Neolitacumonine、Mollinedine和Papaverine的全合成.
关键词: 苄基异喹啉生物碱, Neolitacumonine, Mollinedine, Papaverine
A new general synthetic route towards benzylisoquinoline alkaloids was developed. The key step of this route is Cu-catalyzed cascade oxidation-aromatization of 1-benzyl-3,4-dihydroisoquinolines. The three benzylisoquinoline alkaloids such as neolitacumonine, mollinedine and papaverine were synthesized starting from piperonaldehyde and 3,4-dimethoxybenzaldehyde by 8 steps in 42%, 37% and 37% overall yields, respectively.
Key words: benzylisoquinoline alkaloids, neolitacumonine, mollinedine, papaverine
PDF全文下载地址:
点我下载PDF
