摘要/Abstract

在微波辅助下成功开发了一种由Fe³⁺/O₂催化一锅法合成喹啉-2-甲醛类化合物的方法.以2-甲基喹啉为原料，O₂为醛基中氧的合成子，得到一系列底物适应性较广的喹啉-2-甲醛类化合物，产率48%~80%.初步机理研究表明，该反应可能经历了一个自由基历程.此方法具有操作简便、反应时间短、选择性好等优点.
关键词: 喹啉-2-甲醛, 铁催化, C-H键氧化, 微波辐射
An one-pot iron-catalyzed oxidative formylation of 2-methylquinolines to produce 2-quinoline carboxaldehydes under microwave irradiation has been achieved by employing O₂ as the oxygen donor. The reaction was general for the substrates with a wide range of functional groups, providing a yield of 48%~80%. The preliminary mechanistic studies revealed that the reaction underwent a radical pathway. Advantages of this method include the easy operation, short reaction time and good selectivity.
Key words: 2-quinoline carboxaldehydes, iron catalysis, C-H oxidation, microwave irradiation


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