摘要/Abstract

二聚环色胺生物碱具有相邻的立体位阻较大的全碳季碳中心和良好的生物活性, 作为合成目标一直吸引着合成化学家的广泛关注. 立体选择地构建这类生物碱中相邻的全碳季碳中心是该类型分子化学合成的挑战. 综述总结了二聚环色胺生物碱十二年来的全合成研究进展.
关键词: 二聚环色胺, 生物碱, 相邻季碳, 氧化吲哚, 全合成
As interesting synthetic targets, dimeric cyclotryptamine alkaloids bearing sterically hindered vicinal all-carbon quaternary stereocenters have attracted significant attention from the synthetic community. Stereocontrolled synthesis of the congested all-carbon quaternary stereocenters in these alkaloids presents a formidable challenge. This review summarizes the synthetic efforts towards dimeric cyclotryptamine alkaloids in the last twelve years.
Key words: dimeric cyclotryptamine, alkaloids, vicinal quaternary carbons, oxindole, total synthesis


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