摘要/Abstract

从Ug's胺出发通过4步化学反应合成了一种新的手性PNN三齿配体indan-f-amphox（该配体为f-amphox的姊妹配体），并将其用于铱催化的β-芳基β-酮酸酯的不对称氢化反应，结果显示Ir（III）-indan-f-amphox催化剂对该类反应具有非常高的反应活性和立体选择性（对应选择性最高99%，转化数高达10000），适用于多种β-芳基β-酮酸酯.
关键词: PNN配体, 不对称氢化, β-酮酸酯, f-amphox
A new chiral tridentate PNN ligand, indan-f-amphox (a sister ligand of f-amphox), was synthesized and applied in iridium-catalyzed asymmetric hydrogenation of β-aryl β-ketoesters. A wide range of β-aryl β-ketoesters are reduced using an Ir(III)-indan-f-amphox catalyst with excellent enantioselectivities and reactivities (up to 99% ee, TON=10000).
Key words: PNN ligand, asymmetric hydrogenation, β-ketoesters, f-amphox


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