摘要/Abstract
3-硒氰酸吲哚衍生物由于良好的生物活性，在药物研究方面具有潜在的应用价值.目前，关于3-硒氰酸吲哚的制备方法存在一定的不足，如反应条件苛刻、产率较低、底物适用性较差等.采用微波促进I2催化吲哚与硒氰酸钾的反应，制备了一系列3-硒氰酸吲哚衍生物.与已有方法相比，本方法具有反应速率快、产率高、原子经济性好等优点，为3-硒氰酸吲哚衍生物的制备提供高效的路径.
关键词: 微波辅助反应, 碘催化硒氰酸化, 3-硒氰酸吲哚, 吲哚衍生物, 硒氰酸钾
3-Selenocyanateindole derivatives have potential application in drug research due to their good biological activity. Until now, many methods for the synthesis of 3-selenocyanateindoles have been reported. However, drawbacks still exist, such as harsh reaction conditions, low yields and poor functional groups tolerance. A series of 3-selenocyanateindoles have been synthesized via the microwave-assisted 3-selenocyanation of indole derivatives by using 25 mol% iodine as catalyst, affording the corresponding products in good yields. Compared with the previous methods, this protocol has the advantages of rapid reaction, high yields and good atomic economy, providing an efficient route to 3-selenocyanateindole derivatives.
Key words: microwave-assisted reaction, iodine-catalyzed selenocyanation, 3-selenocyanate iodines, iodine derivatives, potassium selenocyanate
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