摘要/Abstract

探索了锡粉促进下3-羟基-2-氧化吲哚与烯丙基溴的偶联反应，实现了锡粉促进下的亲核取代反应，拓展了锡粉促进下反应类型，并为合成具有潜在生物活性的3，3-二取代-2-氧吲哚提供了简便的方法.该方法具有操作简单、成本低廉等优点.
关键词: 硫酸, 催化, 炔丙醇, 亲核取代
An efficient tin-powder-promoted C-C coupling reaction of 3-aryl-3-hydroxy-2-oxindoles with allyl bromide was disclosed, which makes tin-powder-promoted reactions beyond 1,2-addition to C=O or C=N double bounds, and provides a convenient and facile protocol for the synthesis of potentially bioactive 3,3'-disubstituted-2-oxindoles in good to excellent yields. The method is highly efficient and environmentally benign with low cost and concise manipulation.
Key words: tin powder, 3-hydroxy-2-oxindoles, allylation


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