摘要/Abstract
报道了铜催化的化学选择性N-烯基丙烯酰胺氰异丙基化/环化级联反应，利用该反应可以实现1，3-二氢吡咯-2-酮的合成.丙烯酰胺的自由基环合反应中，用于捕获分子内自由基的基团主要局限于芳基、炔基和氰基，而本工作使用烯胺双键作为内置自由基捕获基团，以丙烯酰胺双键作为自由基受体.该反应的化学选择性可能是由自由基反应的极性匹配原则决定.
关键词: 烯酰胺, 烯烃, 偶氮化合物, 自由基反应, 铜
A copper-catalyzed cyanoisopropylation/cyclization cascade of N-alkenylacrylamides is presented, providing a straightforward and chemoselective access to 1,3-dihydropyrrol-2-ones. In acrylamide-based radical cyclization, radical-trapping groups are mainly restricted to aryl, alkynyl or cyano group. But in this reaction, the enaminic double bond was used as an inbuilt radical trap, while the olefinic bond of the acrylamidyl moiety acted as the radical acceptor. Such chemoselectivity might be attributed to polarity matching.
Key words: enamide, alkene, azo compound, radical reaction, copper
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