摘要/Abstract

碳氢键活化是目前非常活跃的研究领域之一，然而实现碳氢键位点选择性活化是该领域面临的挑战之一.以辅助基团作为导向基，实现碳氢键间位活化引起了众多****的极大关注，经常采用的策略包括模板导向、降冰片烯介导和配体的次级效应.对近年来通过导向基团进行的间位碳氢键活化的研究进行了详细的综述，总结了目前存在的问题，并对今后的发展方向进行了展望.
关键词: 模板导向, 间位活化, 碳氢官能化, 次级效应, 瞬时介导
Transition-metal-catalyzed functionalization of unactivated C-H bonds is a highly attractive strategy for the synthesis of organic molecules, however, regioselective control is a central challenge in this field. The directing group assisted C-H functionalizations such as the use of directing templates and transient mediator, secondary interaction have attracted more attentions from researchers. The meta-C-H functionalizatioin assisted by directing groups are summarized in details. The existing problems and limitations of this field are also included. Finally, the development trend of this area is prospected.
Key words: directed by template, meta-activation, C-H functionalization, secondary interaction, transient mediator


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