摘要/Abstract
马来酰亚胺是一类海洋天然生物碱、生物活性分子和功能材料的重要结构母核，并能转化为琥珀酰亚胺、四氢吡咯及2-吡咯酮等化合物，具有广泛的应用价值.以马来酰亚胺为合成子构建含有马来酰亚胺和琥珀酰亚胺结构单元的化合物已成为有机合成研究热点之一.对马来酰亚胺双键参与的官能化反应进行了综述，重点在马来酰亚胺的Michael加成、氧化偶联和环加成反应.
关键词: 马来酰亚胺, Michael加成, 氧化偶联, 环加成反应
Maleimide, a common motif in a variety of natural alkaloids, has been extensively investigated due to its noteworthy biological activities and optical properties. Additionally, it can be transformed into many important heterocyclic frameworks such as succinimides, pyrrolidines, and 2-pyrrolidones. Thus, a great deal of attention has been focused on the development of new synthetic routes to access polyfunctionalized maleimides. In this article, the recent research progress in functionalization of double bond is reviewed based on maleimides according to Michael addition, oxidative coupling and cycloaddition reaction.
Key words: maleimide, Michael addition, oxidative coupling, cycloaddition reaction
PDF全文下载地址:
点我下载PDF
