摘要/Abstract

α-氨基酸是构成蛋白质的基本结构单元，不仅广泛存在于许多具有重要生物活性的有机分子和天然产物中，而且还可作为有机催化剂或配体用于不对称合成.其中，甘氨酸类化合物在有机合成中是一类非常有用的模块，通过甘氨酸衍生物的α-C（sp³）-H键官能团化高效构建种类丰富的α-取代的α-氨基酸是一种极吸引人的合成策略.介绍了近年来甘氨酸衍生物α-C（sp³）-H活化后与不同有机试剂偶联构建碳-碳键和碳-杂键以及甘氨酸衍生物参与的氧化串联/环化反应的研究进展.
关键词: 甘氨酸, 碳-氢键, 官能团化, 脱氢交叉偶联, 串联环化
α-Amino acids are the units of proteins, which not only widely occur in many biological important compounds and natural products, but also are useful as organic catalysts or ligands for asymmetric synthesis. Among them, glycines are particularly useful building blocks in organic synthesis. Direct C(sp³)-H bond functionalization of glycine derivatives provided an attractive synthesis strategy for the construction of a variety of α-substituted α-amino acids. The recent progress in the α-C(sp³)-H bond activation of glycine derivatives, with various reagents to form carbon-carbon and carbon-heteroatom bond, and oxidative coupling/cyclization reaction involving glycine derivatives is reviewed.
Key words: glycines, C-H bond, functionalization, cross-dehydrogenative-coupling, cascade cyclization


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