摘要/Abstract
三磷酸腺苷（ATP）是各种活细胞内普遍存在的一种高能磷酸化合物，在能量的储存，细胞呼吸作用和酶催化反应等生物活动过程中扮演着重要作用.因此，对于ATP在生物体内的研究至关重要.荧光检测技术具有操作方便、选择性好和灵敏度高等优点，设计合成高效的ATP荧光传感器是近年来生物化学和分析化学领域的研究热点.根据ATP荧光传感器的结构特点和识别原理，将ATP荧光传感器分为金属Zn（Ⅱ）作为键合位点型识别，其它金属离子作为键合位点型识别和静电或氢键作用型识别.基于有机小分子荧光传感器，综述了近年来国内外ATP荧光传感器在分子设计与应用方面的研究进展，并展望了其发展趋势.
关键词: 荧光传感器, 三磷酸腺苷, 生物成像, 有机小分子
Adenosine triphosphate (ATP) is a high-energy phosphate compound commonly existing in various living cells, which plays important roles in the biological activities such as energy storage, cell respiration and enzyme catalytic reactions. Therefore, it is very crucial to ATP research in bio-organism. Fluorescence detection techniques has the advantages of convenient operation, good selectivity and high sensitivity, etc. In recent years, the design and synthesis of efficient ATP fluorescence sensors have become a research focus in the fields of biochemistry and analytical chemistry. According to the structure characteristics, ATP fluorescence chemosensors are categorized as Zn(Ⅱ) metal ions as recognition of bonding site type, other metal ions as recognition of bonding site type and electrostatic or hydrogen bond as interaction type. Based on organic small molecule fluorescence sensors, the recent progress in research of ATP fluorescence sensors in molecular design and application is reviewed, and the prospects for their development are discussed.
Key words: fluorescent chemosensor, adenosine triphosphate, biological imaging, small organic molecules
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