摘要/Abstract
研究了铜催化的脱羰环化生成靛红的方法，使用氧气作为最终的氧化剂.这个互补的C（sp3）—H官能团化方法为合成靛红提供了一种新方案.Cu/O2/Co体系显示出良好的反应性和兼容性，富电子和缺电子的官能团都可以很好地兼容.并基于机理研究和以前的文献报道，提出了一个可能的假设机理.
关键词: 铜催化, 碳氢键活化, 靛红, 脱羰, 氧气
A copper-catalyzed decarbonylation cyclization to form isatins using oxygen as terminal oxidant is developed. This complementary way offers a new protocol for the synthesis of isatins through C(sp3)—H bond functionalization in Cu/O2/Co system. This system shows good reactivity and compatibility. Both electron-rich and electron-deficient functional groups can be tolerated. A postulated mechanism is proposed based on mechanistic studies and previous reports.
Key words: Cu catalyst, C—H bond activation, isatin, decarbonylation, oxygen
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