摘要/Abstract
γ-羟基或烷氧基取代的α，β-不饱和羰基化合物广泛存在于众多天然产物和生物活性分子之中.通过锌催化的区域选择性的氮氧化合物氧化炔烃反应，实现了3-烯-1-炔的4-烷氧化-1-氧化官能团化.该串联反应可以中等到良好的产率得到系列合成上很有用的γ-烷氧基取代的α，β-不饱和酰胺化合物.
关键词: 氧化反应, 1,4-官能团化, 炔烃, 串联反应
γ-Hydroxyl or γ-alkoxyl-substituted α,β-unsaturated carbonyls widely exist in a variety of natural products and bioactive molecules. Herein, the realization of 1,4-functionalization of 3-en-1-ynes with alcohols through zinc-catalyzed regioselective N-oxide oxidation is described. This tandem reaction allows the practical synthesis of a range of valuable γ-alkoxyl-substituted-α,β-unsaturated amides in moderate to good yields.
Key words: oxidation, 1,4-functionalization, alkynes, tandem reaction
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