摘要/Abstract

在PPh₃催化下，橙酮和联烯酸酯可通过陆氏[3＋2]环化反应成功构建含有螺[1-苯并呋喃-3-酮-2，5'-环戊烯]的多环结构单元.该反应条件温和，操作简单，并且底物适用性好，产率高.该方法学的研究为applanatumin A等天然产物的合成奠定了基础.
关键词: 橙酮, 联烯酸酯, 三苯基膦, 陆氏[3+2]环化反应
The PPh₃ catalyzed Lu's[3+2] annulation of aurones with alkenoates has been developed to form spiro-[1-ben-zofuran-3-one-2,5'-cyclopentene] polycyclic moiety. The usefulness of this strategy has been demonstrated by the use of a wide variety of substrates to give desired polycyclic compounds in high yield under mild and simple reaction condition. This methodology research offered a fine entry for synthesis of natural product applanatumin A and its analogues.
Key words: aurones, alkenoate, PPh₃, Lu's[3+2] annulation


PDF全文下载地址:

点我下载PDF