摘要/Abstract
甲基-烯丙基-N-泛酸酰胺（1）具有手性季碳和邻位仲醇结构片段的抗菌剂，可以巧妙通过[2，3]-Wittig重排和钯催化的甲酸还原构建了其分子骨架，以10步反应制备了1.
关键词: [2,3]-Wittig重排, N-Pantothenamide, 手性季碳, 抗菌剂
The synthetic route of allyl-methyl-N-pantothenamide (1) featuring[2,3]-Wittig rearrangement and palladium catalyzed formate reduction to assemble the requisite quaternary carbon with adjacent secondary alcohol has been reported. Our strategy presents a facile synthetic route to access 1 in 10 steps, which also provide a novel inspiration to construct chiral quaternary carbon via asymmetrical[2,3]-Wittig rearrangement.
Key words: [2,3]-Wittig rearrangement, N-pantothenamide, chiral tertiary carbon, antimicrobial
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