摘要/Abstract
在无溶剂下以胺、炔、炔为原料通过“一锅法”串联的反应方便、高效地合成了季碳炔丙基胺.脂肪炔和芳香炔都可以适用于该反应体系.在脂肪炔反应体系中，AgOTf催化促进胺-炔-炔“马氏”反应进程；当芳香炔作为反应底物时，CuBr2/Zn（OTf）2用于共催化剂.该串联反应展示出优异的原子利用效率，为季碳炔丙基胺的制备提供了一种极具有吸引力的绿色合成方法.
关键词: 炔丙基胺, 季碳, 炔, 无溶剂, 绿色有机合成
An efficient and facile method has been developed for the synthesis of quaternary carbon propargylamines via a one-pot tandem reaction of amines, alkynes, and alkynes under neat condition. Both aliphatic and aromatic terminal alkynes are well compatible with the established reaction, with respect to aliphatic alkynes, AgOTf was used as catalyst for the Markovnikov amine-alkyne-alkyne coupling process. When aromatic alkynes were used as substrates, the reaction was promoted by CuBr2/Zn (OTf)2 co-catalytic system. This tandem reaction exhibits excellent atom efficiency and provides an attractive approach to a diverse range of quaternary carbon propargylamines.
Key words: propargylamines, quaternary carbon, alkynes, neat condition, green organic synthesis
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