xm:黄锐敏
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:rmhuang@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海市浦东新区祖冲之路555号
grjj:1999年毕业于中国科学技术大学，获得生物科学专业学士学位。2004年毕业于中国科学院上海生命科学研究院生物化学与细胞生物学研究所，获得细胞生物学专业博士学位。同年10月赴美国纪念斯隆凯特琳癌症研究中心开展研究工作。2016年3月加入中国科学院上海药物研究所工作至今，现任中国科学院上海药物研究所“海外高层次人才引进计划”研究员、分子影像中心课题组长、所级公共技术服务中心分子影像技术服务部主任、博士生导师。

yjfx:1.肿瘤分子影像学研究
2.肿瘤耐药、转移复发相关基因代谢功能研究
dblz:1. Dalangood S*, Zhu Z*, Ma Z, Li J, Zeng Q, Yan Y, Shen B, Yan J#, Huang R#. Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer. Theranostics, 10(22), 10078-91, 2020.

2. Guo H, Pu M, Tai Y, Chen Y, Lu H, Qiao J, Wang G, Chen J, Qi X, Huang R#, Tao Z#, Ren J#. Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy. Cell Death Differ, 2020. (Online ahead of print)

3. Li Y*, Zhang H*, Fan L, Mou J, Yin Y, Peng C, Chen Y, Lu H, Zhao L, Tao Z, Chen J, Wang Y, Qi X, Huang R#, Ren J#. MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability. Oncogene, 39(17), 3473-88, 2020.

4. Liu J*, Fang T*, Li M*, Song Y, Li J, Xue Z, Li J, Bu D, Liu W, Zeng Q, Zhang Y, Yun S#, Huang R#, Yan J#. Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase. Sci Rep, 9(1), 19703, 2019.

5. Yan H, Chen X, Li Y, Fan L, Tai Y, Zhou Y, Chen Y, Qi X#, Huang R#, Ren J#. MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer. Am J Cancer Res, 9(2), 312-29, 2019.

6. Li C*, Huang S*, Guo J, Wang C, Huang Z, Huang R#, Liu L, Liang S#, Wang H#. Metabolic Evaluation of MYCN-Amplified Neuroblastoma by 4-[18F]FGln PET Imaging. Mol Imaging Biol, 21(6), 1117-26, 2019.

7. Cao YP*, Sun JY*, Li MQ*, Dong Y, Zhang YH, Yan J#, Huang RM#, Yan X#. Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells. Acta Pharmacol Sin, 40(8), 1076-84, 2019.

8. Ren W*, Zhang J*, Peng C*, Xiang H, Chen J, Peng C, Zhu W, Huang R#, Zhang H#, Hu Y#. Fluorescent Imaging of β-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe. Bioconjug Chem, 29(10), 3459-66, 2018.

9. Fang T*, Liu DD*, Ning HM*, Liu D, Sun JY, Huang XJ, Dong Y, Geng MY, Yun SF#, Yan J#, Huang RM#. Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3. Acta Pharmacol Sin, 39(12), 1885-93, 2018.

10. Huang X*, Zhu H*, Gao Z, Li J, Zhuang J, Dong Y, Shen B, Li M, Zhou H, Guo H#, Huang R#, Yan J#. Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p. J Biol Chem, 293(18), 6693-706, 2018.

11. Huang R*, Harmsen S*, Samii JM, Karabeber H, Pitter KL, Holland EC, Kircher MF. High precision imaging of microscopic spread of glioblastoma with a targeted ultrasensitive SERRS molecular imaging probe. Theranostics, 6(8), 1075-84, 2016.

12. Harmsen S*, Huang R*, Wall MA, Karabeber H, Samii JM, Spaliviero M, White JR, Monette S, O’Connor R, Pitter KL, Sastra SA, Saborowski M, Holland EC, Singer S, Olive KP, Lowe SW, Blasberg RG, Kircher MF. Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging. Sci Transl Med, 7(271), 271ra7, 2015.

13. Zhang H*, Huang R*, Cheung NK, Guo H, Zanzonico PB, Thaler HT, Lewis JS, Blasberg RG. Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res, 20(8), 2182-91, 2014.

14. Huang R, Vider J, Kovar JL, Olive DM, Mellinghoff IK, Mayer-Kuckuk P, Kircher MF, Blasberg RG. Integrin αvβ3-targeted IRDye 800CW near-infrared imaging of glioblastoma. Clin Cancer Res, 18(20), 5731-40, 2012.

15. Huang R, Cheung NK, Vider J, Cheung IY, Gerald WL, Tickoo SK, Holland EC, Blasberg RG. MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas. FASEB J, 25(12), 4138-49, 2011.

16. Huang R*, Xing Z*, Luan Z, Wu T, Wu X, Hu G. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. Cancer Res, 63(13), 3375-82, 2003.

17. Huang R*, Wu T*, Xu L, Liu A, Ji Y, Hu G. Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells. FASEB J, 16(3), 293-301, 2002.

jyjl:1999.9–2004.7中科院生物化学与细胞生物学研究所，细胞生物学，博士