xm:唐炜
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:tangwei@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海浦东张江祖冲之路555号
grjj: 2005年于中国科学院上海药物研究所获得博士学位，现任上海药物研究所研究员、课题组长。从事难治性自身免疫性疾病的新药研发，以及药物干预新靶点和生物标志物的应用基础研究。研制了数个候选新药（1.1类化学药物）进入临床研究，在疾病病理机制和生物标志物研究方面也取得了一定进展，已获国内外专利授权20余项，在SCI期刊上发表论文80余篇。主持国家重大科技专项、国家自然科学基金、上海市科委等项目；获得中国药理学会、上海药理学会、上海药学会等奖项及荣誉。

yjfx:针对难治性自身免疫性疾病（银屑病、炎症性肠病、慢性肾炎等）和病毒感染性疾病开展创新药物的发现和基础研究。
dblz: 1.Li H, Feng C, Fan C, Yang Y, Yang X, Lu H, Lu Q, Zhu F, Xiang C, Zhang Z, He P, Zuo J, Tang W. Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis. Cell Death Dis. 2020 Apr 24;11(4):271.

2.Wu Y, Wu B, Zhang Z, Lu H, Fan C, Qi Q, Gao Y, Li H, Feng C, Zuo J, Tang W. Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way. FASEB J. 2020 Apr 17.

3.Li H, Li J, Zhang X, Feng C, Fan C, Yang X, Zhang R, Zhu F, Zhou Y, Xu Y, Liu H, Tang W*. DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling. Biochem Pharmacol. 2020 Apr 3:113958.

4.Li H, Fan C, Lu H, Feng C, He P, Yang X, Xiang C, Zuo J*, Tang W*.. Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions. Acta Pharm Sin B. 2020 Mar;10(3):447-461.

5.Xie Z, Wu B, Liu Y, Ren W, Tong L, Xiang C, Wei A, Gao Y, Zeng L, Xie H*, Tang W*, Hu Y*. Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders. J Med Chem. 2020 Feb 13;63(3):1397-1414.

6.Lu H, Li H, Fan C, Qi Q, Yan Y, Wu Y, Feng C, Wu B, Gao Y, Zuo JP*, WeiTang*. RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-Immuno crosstalk. Biochem Pharmacol. 2020 Feb;172:113751

7.Zhang Z, Wu Y, Wu B, Qi Q, Li H, Lu H, Fan C, Feng C, Zuo J*, Niu L*, Tang W*. DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models. Arthritis Res Ther. 2019 Dec 16;21(1):290.

8.Wu B, Wu YW*, Tang W*. Heme Catabolic Pathway in Inflammation and Immune Disorders. Front. Pharmacol. 2019 Jul 24;10:825.

9.Yang M, Li H, Zhang Q, Wu QH, Li G, Chen KX, Guo YW*, Tang W*, Li XW*. Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents. Bioorg Med Chem. 2019 Aug 1;27(15):3469-3476.

10.Zhang X, Dong G, Li H, Chen W, Li J, Feng C, Gu Z, Zhu F, Zhang R, Li M, Tang W*, Liu H*, Xu Y*. Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Anti-Psoriasis Agent. J Med Chem. 2019 Jun 13;62(11):5579-5593.

11.Li H, Fan C, Feng C, Wu Y, Lu H, He P, Yang X, Zhu F, Qi Q, Gao Y, *Zuo J, *Tang W. Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity. Br J Pharmacol. 2019 Jul;176(13):2209-2226.

12.Li G, Li H, Zhang Q, Yang M, Gu YC, Liang LF*, Tang W*, Guo YW*. Rare Cembranoids from Chinese Soft Coral Sarcophyton ehrenbergi: Structural and Stereochemical Studies. J Org Chem. 2019 May 3;84(9):5091-5098.

13.He S, Liu X, Lin Z, Liu Y, Gu L, Zhou H*, Tang W*, Zuo J*. Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage. Arthritis Res Ther. 2019 Jan 29;21(1):40.

14.Yang M, Liang LF, Li H, Tang W*, Guo YW*. A new 5α,8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral Sinularia sp. Nat Prod Res. 2019 Jan 29:1-6.

15.Liu J, Li H, Chen K, Zuo J, Guo YW, Tang W*, Li XW*. Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents. J Med Chem. 2018 Nov 30.

16.Wang XF, Li H, Jiang K, Wang QQ, Zheng YH, Tang W*, Tan CH*. Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells. Fitoterapia. 2018 Oct;130:61-65.

17.Li H, Zuo J*, Tang W*. Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Front Pharmacol. 2018 Oct 17;9:1048.

18.Yan YX, Shao MJ, Qi Q, Xu YS, Yang XQ, Zhu FH, He SJ, He PL, Feng CL, Wu YW, Li H, Tang W*, Zuo JP*. Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages. Acta Pharmacol Sin. 2018 Oct;39(10):1633-1644.

19.Lin ZM, Ma M, Li H, Qi Q, Liu YT, Yan YX, Shen YF, Yang XQ, Zhu FH, He SJ, Tang W*, Zuo JP*. Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17. Pharmacol Res. 2018 Mar;129:443-452.

20.Qi Q, Li H, Lin ZM, Yang XQ, Zhu FH, Liu YT, Shao MJ, Zhang LY, Xu YS, Yan YX, Sun LL, He SJ, Tang W*, Zuo JP*. (5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fcγ receptor signaling. Acta Pharmacol Sin. 2018 Jan;39(1):107-116.

jyjl:2002–2005年中国科学院上海药物研究所，研究生/理学博士学位