中国科学院上海药物研究所导师教师师资介绍简介-李静雅

本站小编 Free考研考试/2021-02-10

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yjfx:专注于代谢性疾病的新病理机制、新靶标论证和新分子实体等发现研究
dblz: 1.Li, BH; Zhang, M; Duan, YN; Shuai, L; Jiang, HW; Jia Li; Nan, FJ*, and Li, JY*. Pyrazolone Derivative C29 Protects Against HFD-induced Obesity in Mice via Activation of AMPK in Adipose Tissue. Acta Pharmacologica Sinica 2020, in press

2.Sun, SM#; Xie, ZF#; Zhang, YM#; Zhang XW; Zhou CD; Yin, JP; Yu, YY; Cui, SC; Jiang, HW; Li, J; Nan, FJ*; Li JY*. AMPK Activator C24 Inhibits Hepatic Lipogenesis and Ameliorates Dyslipidemia in HFHC Diet Induced Animal Models. Acta Pharmacologica Sinica 2020, in press

3.Yu, YY; Cui, SC; Zheng, TN; Ma, HJ; Xie, ZF; Jiang, HW; Li, YF; Zhu, KX; Huang, CG; Li, J*; Li, JY*. Sarsasapogenin Improves Adipose Tissue Inflammation and Ameliorates Insulin Resistance in High-Fat Diet-Fed C57BL/6J Mice. Acta Pharmacologica Sinica 2020, in press

4.Xie, ZF; Jiang, HW; Liu, W; Zhang, XW; Chen, DK; Sun, SM; Zhou, CD; Liu, J; Bao, S; Wang, XC; Zhang, YN; Li, J; Hu, LH*; Li, JY*. The Triterpenoid Sapogenin (2α-OH-Protopanoxadiol) Ameliorates Metabolic Syndrome via the Intestinal FXR/GLP-1 Axis Through Gut Microbiota Remodelling. Cell Death and Disease 2020, in press

5.Jiang, HW; Zhou, XE; Shi, JJ; Zhou, Z; Zhao, GG; Zhang, XW; Sun, YL; Suino-Powell, K ; Ma, L; Gao, H; Xu, XY; Li, J*; Li JY*; Melcher, K; Xu, H*.; Yi, W*. Identification and Structural Insight of an Effective PPARr Modulator with Improved Therapeutic Index for Anti-diabetic Drug Discovery. CHEMICAL SCIENCE, 2020, 11:2260-2268

6.Shuai, L#; Zhang, LN#; Li, BH#; Tang, CL; Wu, LY; Li, J* and Li, JY*.SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue. DIABETES, 2019, 68: 1449-1461.

7.Jiang, HW; Jin, J; Duan, YN; Xie, ZF; Li, YF; Gao, AH; Gu, M; Zhang, XW; Peng, C; Xia, CM; Dong, TC; Li, H; Yu, LF; Tang, J; Yang, F*; Li, JY* and Li, J*. Mitochondrial Uncoupling Coordinated with PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation. DIABETES, 2019, 68:2197-2209.

8.Wu, LY#; Xia, MF#; Duan, YN#; Zhang, LN; Jiang, HW; Hu, XB; Yan HM; Zhang, YQ; Gu, YS; Shi, HC; Li, J*; Gao, X* and Li, JY*. Berberine Promotes the Recruitment and Activation of Brown Adipose Tissue in Mice and Humans. CELL DEATH & DISEASE, 2019,10:468.

9.Li,SL#; Qin,C#; Cui,SC#; Xu,HL; Wu,FS; Wang,JW; Su,MB ; Fang,XY; Li,D; Jiao,Q; Zhang,M; Xia,CM; Zhu,LL; Wang,R; Li,J; Jiang,HL; Zhao,ZJ* ; Li, JY*; Li,HL*. Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes. JOURNAL OF MEDICINAL CHEMISTRY 2019, 62:2348-2361.

10.Wu,LY; Zhang,LN; Li,BH; Duan,YN; Xie,ZF; Shuai,L; Li,J*; Li,JY*. AMP-activated protein kinase (AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue. FRONTIERS IN PHYSIOLOGY. 2018,9:122.

11.LT (Nie, Litong); Shuai, L (Shuai, Lin); Zhu, MR (Zhu, Mingrui); Liu, P (Liu, Ping); Xie, ZF (Xie, Zhi-Fu); Jiang, SW (Jiang, Shangwen); Jiang, HW (Jiang, Hao-Wen); Li, J (Li, Jia); Zhao, YM (Zhao, Yingming); Li, JY* (Li, Jing-Ya); Tan, MJ* (Tan, Minjia). The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model Nie, MOLECULAR & CELLULAR PROTEOMICS 2017, 16:1324-1334

12.Li SL, Xu HL, Cui SC, Wu FS, Zhang YL, Su MB, Gong YH, Qiu SB, Jiao Q, Qin C, Shan JW, Zhang M, Wang JW, Yin Q, Xu MH, Liu XF, Wang R, Zhu LL, Li J, Xu YF, Jiang HL, Zhao ZJ*, Li JY*, Li HL*. Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H‐benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes. JOURNAL OF MEDICINAL CHEMISTRY 2016, 59:6772-6790

13.Li YY, Yu LF, Zhang LN, Qiu BY, Su MB, Wu F, Chen DK, Pang T, Gu M, Zhang W, Ma WP, Jiang HW, Li JY*, Nan FJ*, Li J*. Novel Small-Molecule AMPK Activator Orally Exerts Beneficial Effects on Diabetic db/db Mice.TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013, 273:325-334.

14.Zhang LN, Xu L, Zhou HY, Wu LY, Li YY, Pang T, Xia CM, Qiu BY, Gu M, Dong TC, Li JY*, Shen JK*, Jia Li*. A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obese by modulating energy expenditure and food intake.small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLOS ONE 2013, 8(8):e72092.

15.Zhang LN, Zhou HY, Fu YY, Li YY, Wu F, Gu M, Wu LY, Xia CM, Dong TC, Li JY*, Shen JK*, Li J*. Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice. DIABETES 2013, 62:1297-1307.

16.Qiu BY, Turner N, Li YY, Gu M, Huang MW, Wu F, Pang T, Nan FJ, Ye JM, Li JY*, Li J*. A high-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. DIABETES 2010, 59:256-265.

17.Turner N, Li JY#, Gosby A, To S, Cheng Z, Miyoshi H, Taketo M, Cooney G, Kraegen E, David J, Hu LH*, Li J*, Ye JM*. Berberine, and its more biologically available derivative dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMPK and improve insulin action. DIABETES 2008, 57:1414-1418.