xm:谢岑
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:xiecen@simm.ac.cn
grzy:
zjlb:研究员；新药；
zw:课题组长
txdz:上海浦东张江海科路501号
grjj:谢岑，中国科学院上海药物研究所研究员、课题组长。2013年于中国科学院上海药物研究所获得博士学位，毕业后赴美国国立卫生研究院从事博士后研究，2018年10月回到上海药物研究所，担任课题组长。实验室主要针对肥胖、非酒精性脂肪肝（NAFLD/NASH）、糖尿病和肿瘤等代谢紊乱相关疾病，以肠道微生态、胆汁酸和脂质为研究对象，借助多种组学手段，研究疾病进程中的代谢调控机制，并开展新药物靶点的发现和创新药物研究。共发表学术论文50余篇，其中以第一或通讯作者署名发表学术论文于Nature Medicine（2017，2018）、Cell Metabolism、Nature Communications、Diabetes等学术期刊20余篇，总影响因子逾300，总引用2000余次。相关研究成果申请美国专利2项并获得授权1项。
yjfx:代谢紊乱相关疾病（肥胖、脂肪肝、糖尿病和肿瘤）的代谢调控机制研究和新药物靶标发现
dblz:（SCI论文清单：https://www.ncbi.nlm.nih.gov/pubmed?term=Xie%2C%20Cen%5BAuthor%5D）1.Liu H, Xu F, Gao Y, Pang Y, Xie C*, Jiang C*. An integrated LC-MS/MS strategy for quantifying the oxidative-redox metabolome in multiple biological samples. Anal Chem. 2020, 92: 8810-8818.2.Takahashi S#, Luo Y#, Ranjit S#, Xie C#, Libby AE#, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M*. Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice. J Biol Chem. 2020, 295:4733-4747.3.Xie C#*, Takahashi S#, Brocker CN#, He S, Chen L, Xie G, Jang K, Gao X, Krausz KW, Qu A, Levi M, Gonzalez FJ*. Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport. Biochim Biophys Acta Mol Cell Biol Lipids.2019, 1864: 1396-1411.4.Sun L#, Xie C#, Wang G#, Wu Y#, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C*. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nat Med. 2018, 24: 1919-1929.5.Xie C, Gao X*, Sun D, Zhang Y, Krausz KW, Qin X, Gonzalez FJ*. Metabolic profiling of the novel HIF2α inhibitor PT2385 in vivo and in vitro. Drug Metab Dispos. 2018, 46: 336-345.6.Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Liu Y, Shah YM, Wu Y*, Jiang C*, Gonzalez FJ*. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017, 23: 1298-1308.7.Li G#*, Xie C#, Lu S, Nichols RG, Tian Y, Li L, Ma Y, Brocker C, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ*. Intermittent fasting promotes browning of white adipose tissue and improves metabolic syndrome via shaping the gut microbiota. Cell Metab. 2017, 26: 672-685.e4.8.Xie C, Jiang C*, Shi J, Gao X, Sun D, Sun L, Wang T, Takahashi S, Anitha M, Krausz KW, Patterson AD, Gonzalez FJ*. An intestinal farnesoid X receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice. Diabetes. 2017, 66: 613-626.9.Shi J#, Xie C#, Liu H, Krausz KW, Bewley CA, Zhang S, Tang L, Zhou Z*, Gonzalez FJ*. Metabolism and bioactivation of fluorochloridone, a novel selective herbicide, in vivo and in vitro. Environ Sci Technol. 2016, 50: 9652-9660.10.Gao X#, Xie C#, Wang Y, Luo Y, Yagai T, Sun D, Qin X, Krausz KW, Gonzalez FJ*. The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4. Biochem Pharmacol. 2016, 119: 93-104.11.Jiang C#, Xie C#, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD*, Gonzalez FJ*. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun. 2015, 6: 10166.12.Xie C, Zhong D and Chen X. A fragmentation-based method for the differentiation of glutathione conjugates by high-resolution mass spectrometry with electrospray ionization. Anal Chim Acta. 2013, 788: 89-98.13.Xie C, Zhou J, Guo Z, Diao X, Gao Z, Zhong D, Jiang H, Zhang L and Chen X. Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013, 168: 1687-1706.14.Xie C, Zhong D, Yu K and Chen X. Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS. Bioanalysis. 2012, 4: 937-959.15.Xie C, Zhong D and Chen X. Identification of the ortho-benzoquinone intermediate of 5-O-caffeoylquinic acid in vitro and in vivo: comparison of bioactivation under normal and pathological situations. Drug Metab Dispos. 2011, 40: 1628-1640.
jyjl:浙江大学，药物制剂，理学学士
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