xm:徐华强
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:eric.xu@simm.ac.cn
grzy:
zjlb:研究员
zw:中科院受体结构与功能重点实验室主任、药物靶标结构与功能中心主任
txdz:上海市浦东新区张江高科技园区海科路501号
grjj:徐华强，毕业于清华大学，在1985与1988年分别获得学士与硕士学位，随后于1994年获得美国德州西南医学中心博士学位，而后两年在美国麻省理工学院从事博士后研究。1996年到2002年，先后在葛兰素威康研究所和美国葛兰素史克任研究员。2002年任美国Van Andel研究所结构科学实验室主任，2007年提升为杰出教授和药物研发中心主任。2010年7月回到中国科学院上海药物研究所创建药物靶结构与功能中心，任中心主任。2012年8月筹建中国科学院受体结构与功能重点实验室，2013年4月批复成立，任实验室主任。2019年全职加入中科院上海药物研究所。

yjfx:主要研究领域集中在核激素受体、肝脏生长因子(HGF)及其受体Met酪氨酸激酶、GPCR和植物激素等的结构和药物研发。

dblz:1.Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang,Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen，Caiping Tian, Zi-jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen,Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H.Eric Xu, Yan Zhang & Jin-Peng Sun. Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex.Nature. Published: 06 January 2021,https://www.nature.com/articles/s41586-020-03083-w

2.Ting-Hai Xu, Minmin Liu, X Edward Zhou, Gangning Liang, Gongpu Zhao,H Eric Xu,Karsten Melcher, Peter A Jones. Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.Nature2020,586 (7827):151-155.

3.Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y,Xu HE. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.Science,26 Jun 2020:368(6498): 1499–1504.Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C,Xu HE, Xie XQ. Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex.Cell. 2020 Feb 20;180(4):645-654.e13. doi: 10.1016/j.cell.2020.01.007. Epub 2020 Jan 30.

4.Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D1, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP,Xu HE, Zhang Y. Structure and dynamics of the active human parathyroid hormone receptor-1.Science.2019 Apr 12;364(6436):148-153. doi: 10.1126/science.aav7942.

5.Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S,Xu HE. Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.Nature. 2018 Jun;558(7711):553-558.

6.Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Crystal structure of Frizzled 4 receptor in ligand-free state.Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22.

7.Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K,Xu HE. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.Cell.2017 Jul 27;170(3):457-469.e13. doi: 10.1016/j.cell.2017.07.002.

8.Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MHE, Zhang C, Moeller A, West GM, Eps NV, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet1 S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad C, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I , Fromme R, Yi Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B6, Caffrey M, Jiang H, Chapman HN, Spence JCH, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens, RC, Cherezov V, Melcher K, and Xu HE. (2015) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22. PMID: **

9.Pal K, Melcher K*, andHE Xu* (2013) Structure Modelling Using Genetically-Engineered Crosslinking.Cell2013 Dec 5;155(6):1207-8. doi: 10.1016/j.cell.2013.11.018.

10.Jiang L, Liu X, Xiong GS, Liu HH, Chen F, Wang L, Meng XB, Liu GF, Yu Y, Yuan YD, Yi W, Zhao LH, Ma HL, He YZ, Wu ZS, Melcher K, Qian Q,Xu HE*, Wang YH* & Li JY*. (2013) DWARF 53 acts as a repressor of strigolactone signalling in rice.Nature. 2013 Dec 19;504(7480):401-5. doi: 10.1038/nature12870. Epub 2013 Dec 11.

11.Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong E-L*,Xu HE*, and Melcher K*. (2013) Structural basis for molecular recognition of folic acid by folate receptors.Nature. 2013 Aug 22;500(7463):486-9. doi: 10.1038/nature12327. Epub 2013 Jul 14. PMID: ** (Highlighted by Chemical Engineering News).

12.Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC*,Xu HE*. (2013) Structural Basis for Molecular Recognition at Serotonin Receptors.Science.2013 May 3;340(6132):610-4. doi: 10.1126/science.**. PMID: **; PMCID: PMC** (Commented by Science, Nature, and Chemical Engineering News)

13.Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W,Xu HE, Cherezov V, Roth BL, Stevens RC. (2013) Structural Features for Functional Selectivity at Serotonin Receptors.Science. 2013 May 3;340(6132):615-9. doi: 10.1126/science.**. PMID: **; PMCID: PMC** (Commented by Science, Nature, and Chemical Engineering News)

14.Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K,Xu HE. (2012) Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases.Science, 2012 Jan 6;335(6064):85-8. Nov 24. [Epub ahead of print] (Commented by Science). PMID: **; PMCID: PMC**

15.Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK,Xu HE(2009) A gate-latch-lock mechanism for hormone signaling by abscisic acid receptors.Nature2009 Dec 3;462(7273):602-8 (Cover Article, featured as one of top 10 breakthroughs of 2009 by Science). PMID: **; PMCID: PMC**