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Na Suo, Yu-e Guo, Bingqing He, Haifeng Gu, Xin Xie*. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia, 2019 Jul;67(7):1320-1332. Chenwen Huang, Wanzhi Tu, Yanbin Fu, Xin Xie*. Chemical-induced cardiac reprogramming in vivo. Cell Research, 2018 Jun;28(6):686-689. Haikun Song, Hexuan Li, Shimeng Guo, Yuyin Pan, Yuhua Fu, Zijian Zhou, Zhaoyang Li, Xue Wen, Xiaoli Sun, Bingqing He, Haifeng Gu, Youhong Hu, Xin Xie*, Boxun Lu*. Targeting Gpr52 Lowers Mutant HTT Levels and Rescues Huntington’s Disease-associated Phenotypes. Brain, 2018 Jun 1;141(6):1782-1798. Ren Guo, Wei Tang, Qianting Yuan, Lijian Hui, Xin Wang, Xin Xie*. Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor, Stem Cell Reports, 2017, Aug 8;9(2):499-512. Jiali Jin, Jian Liu, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie*, Ping Wang*. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications, 2016 Nov 25;7:13594. Changsheng Du, Yanhui Duan, Hui Chai, Yingying Cai, Wei Wei, Jie Lv, Xin Xie*. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.Nature Communications, 2016 Apr 4;7:11120. Yuan Long, Min Wang, Haifeng Gu, Xin Xie*. Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells. Cell Research, 2015 Oct;25(10):1171-4. Yanbin Fu, Chenwen Huang, Xinxiu Xu, Haifeng Gu, Youqiong Ye, Cizhong Jiang, Zilong Qiu, Xin Xie*. Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Research, 2015 Sep;25(9):1013-24. 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Cell Research. 2013 Jan;23(1):131-41. Jie Lv, Changsheng Du, Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie*. The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. Journal of Biological Chemistry.2012 Aug 17; 287(34):28656-65. Chang-Sheng Du, Xin Xie*. G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis. Cell Research. 2012 Jul; 22(7):1108-28. Liefeng Wang, Changsheng Du, Jie Lv, Wei Wei, Ye Cui, Xin Xie*. Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis. Journal of Immunology. 2011;187(5):2336-45. Quan Wang, Xinxiu Xu, Jun Li, Jing Liu, Haifeng Gu, Ru Zhang, Jiekai Chen, Yin Kuang, Jian Fei, Cong Jiang, Ping Wang, Duanqing Pei, Sheng Ding, Xin Xie*. Lithium, an anti-Psychotic Drug, Greatly Enhances the Generation of Induced Pluripotent Stem Cells. Cell Research. 2011;21(10):1424-35. He X, Fang L, Wang J, Yi Y, Zhang S, Xie X*. Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Research 2008 Nov 1; 68(21):8678-86. jyjl:美国新泽西医科和牙科大学神经科学系，博士研究生北京大学化学系，本科生（河南信阳陆军学院军训一年） gzjl: 中国科学院上海药物研究所，研究员，课题组长 国家新药筛选中心，历任模型建立II部主管, 副主任 信谊药厂药物研究所，对外合作部主任 美国新泽西医科和牙科大学神经科学系，博士后 ktxm:基金委重点项目,中链脂肪酸受体作为抗炎症性肠病药物作用新靶点的研究,项目负责人科技部干细胞研究重大科学研究计划,小分子药物调控细胞命运及其机理研究,首席科学家 ryhj: 中国青年科技奖 全国三八红旗手 第十届中国青年女科学家奖 享受国务院政府特殊津贴专家 第六届上海青年科技英才提名奖 第六届药明康德生命化学****奖 中科院上海分院系统****科技创新人才 新世纪百千****才工程国家级人选 xpwj:http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202008/P.jpg kycg:谢欣研究员长期从事基于G蛋白偶联受体（GPCR）和干细胞的重大疾病新机制、药物作用新靶点及生物活性新分子研究。其研究策略新颖，采用化学生物学和分子生物学结合的研究手段，利用老药、天然产物和特色小分子探针推进新靶点/新机制的研究，而其中发现的新活性分子一方面可作为工具药继续推进重大疾病的新机制研究，另一方面可以向药物先导化合物转化。近年来，谢欣课题组发现数个GPCR（CysLT1，A2B和KOR）是治疗自身免疫性疾病多发性硬化症（MS）的潜在药靶，揭示数个老药可有效控制MS，并提出免疫抑制和髓鞘再生的联合策略是治疗这类复杂疾病的新思路。在化学诱导体细胞重编程方面，在国际上首次实现全化学诱导小鼠体内原位非心肌细胞向心肌细胞的重编程，并实现功能性修复。实验室也是国际上少数能实现全化学诱导iPS的实验室之一，为化学诱导体细胞重编程其在药物研发领域的应用提出新概念新方法。迄今已在Nature，Cell Research，Nature Communications，PNAS等知名学刊上发表论文100余篇，他引>2500次；申请发明专利30余项，获授权10余项。作为主要发明人研发的靶向GPCR的抗前列腺增生1.1类新药DC042已获得临床研究批件，并实现成果转让。 shrz:2008.12－至今, Acta Pharmacologica Sinica编委2014.05－至今, 中国细胞生物学学会干细胞生物学分会，委员2018－至今，上海市药理学会，委员
