xm:王贺瑶
xb:女
zc:研究员
xl:博士
dh:+86-
cz:86-
dzyj:hywang@simm.ac.cn
grzy:
zjlb:研究员
zw:中科院上海药物所研究员、博士生导师、研究组长
txdz:上海市浦东新区祖冲之路555号
grjj:中国科学院上海药物研究所研究员、研究组长。1997年毕业于日本神户大学，获医学博士学位，2005年加入上海药物研究所。长期从事代谢内分泌病学研究，目前主要研究方向是代谢失调性疾病的新药发现与药理药效学研究，以及代谢失调性疾病发生发展分子机制和药物新靶标确认研究。带领团队围绕糖脂代谢建立了系列分子、细胞及动物体内抗肥胖、糖尿病、高脂血症、及高尿酸血症药物发现与药理药效学研究评价平台，发现了数个分别具有减肥、降糖、降脂和降低血尿酸水平、具有自主知识产权、且有良好开发前景的候选化合物，并对其中部分活性化合物进行了详细的药理药效学研究。主持国家“863”、国家科技重大专项、国家自然科学基金、中国科学院战略性先导科技专项（A类）、上海市生物医药重点科技攻关项目，参加“973”、上海市中西医结合临床重大项目等多项，目前已在Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Endocrine, Journal of Medicinal Chemistry 等杂志发表SCI论文八十余篇。申请专利36项, 其中24项获中国发明专利授权。
yjfx:主要研究方向为代谢失调性疾病的新药发现与药理药效学研究，以及代谢失调性疾病发生发展分子机制和药物新靶标确认研究。选择与代谢性疾病相关(肥胖、糖尿病、高脂、高尿酸血症、脂肪肝以及皮肤色素代谢失调)的G-蛋白偶联受体、酶分子作为药物筛选的主要靶点，建立细胞或分子水平的高通量筛选模型，通过筛选和评价，从中发现具有良好开发前景的药物先导化合物。围绕脂类吸收、转运、清除等生物学过程及其调控机制，从分子、细胞和在体层次探索脂毒性引起的胰岛功能损伤和脂质代谢紊乱在肥胖诱导的胰岛素抵抗中的分子机制及其药物干预手段。研究组与国内外多个研究机构、大学和企业紧密合作，共同开展代谢失调性疾病新药和发病机制研究，为药物研发提供平台和新的研究思路。
dblz: (近五年发表部分论文)1. Dou, Hui-Xia; Wang, Ting; Su, Hai-Xia; Gao, Ding-Ding; Xu, Ye-Chun; Li, Ying-Xia; Wang, He-Yao* . Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes. Endocrine, 2020, 67(3): 587-596.2. Sun, Peng; Li, Kai; Wang, Ting; Ji, Jun; Wang, Yan; Chen, Kai-Xian; Jia, Qi; Li, Yi-Ming*; Wang, He-Yao*. Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes. Journal of Agricultural and Food Chemistry, 2019, 67(32): 8839-8846.3. He, Yu-long; Dou, Hui-xia; Gao, Ding-ding; Wang, Ting; Zhang, Ming-ming*; Wang, He-yao*; Li, Ying-Xia*. Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor. Bioorganic & Medicinal Chemistry, 2019, 27(19): 0-UNSP 115015.4. Sheng, Ren; Yang, Liu; Zhang, Yan-Chun; Xing, En-Ming; Shi, Rui; Wen Xiao-An; Wang, He-Yao*; Sun, Hong-Bin* Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design. Bioorganic & Medicinal Chemistry Letters, 2018, 2018(28): 2599-2604.5. Gao, Ding-Ding; Dou, Hui-Xia; Su, Hai-Xia; Zhang, Ming-Ming; Wang, Ting; Liu, Qiu-Feng; Cai, Hai-Yan; Ding, Hai-Peng; Yang, Zhuo; Zhu, Wei-Liang*; Xu, Ye-Chun*; Wang, He-Yao*; Li, Ying-Xia* From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4. European Journal of Medicinal Chemistry, 2018, 2018(154): 44-59.6. Sun, Peng; Zhu, Jing-Jie; Wang, Ting; Huang, Qi; Zhou, Yu-Ren; Yu, Bang-Wei; Jiang, Hua-Liang; Wang, He-Yao*. Benzbromarone aggravates hepatic steatosis in obese individuals. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018, 1864(6): 2067-2077.7. Pu, De-Bing; Wang, Ting; Zhang, Xing-Jie; Gao, Jun-Bo; Zhang, Ru-Han; Li, Xiao-Nian; Wang, Yong -Mei; Li, Xiao-Li*; Wang, He-Yao*; Xiao, Wei-Lie*. Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis. RSC Advances, 2018, 8(12): 6425-6435.8. Cai, Hai-Yan; Wang, Ting; Yang, Zhuo; Xu, Zhi-Jian; Wang, Gui-Min; Wang, He-Yao*; Zhu, Wei-Liang*; Chen, Kai-Xian. Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors. Journal of Chemical Information and Modeling, 2017, 57(9): 2329-2335.9. Yan, Jian-Wei; Wang, Gai-Hong; Dang, Xiang-Yu; Guo, Bin-Bin; Chen, Wu-Hong; Wang, Ting; Zeng, Li-Min; Wang, He-Yao*; Hu, You-Hong*. Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety. Bioorganic & Medicinal Chemistry, 2017, 25(17): 4701-4714.10. Huang, Qi; Wang, Ting; Yang, Liu; Wang, He-Yao*. Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK. International Journal of Molecular Sciences, 2017, 18(5): 1063.11. Zhu, Jing-Jie; Huang, Jun-Shang; Wang, Ting; Ji, Jun; Hou, Ai-Jun*; Wang, He-Yao*. Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression. Endocrine, 2017, 56(1): 73-81.12. Huang, Qi; Wang, Ting; Wang, He-Yao*. Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression. Acta Pharmacologica Sinica, 2017, 38(2): 192-200.13. Li, He; Huang, Qi; Chen, Cheng; Xu, Bin; Wang, He-Yao*; Long, Ya-Qiu*. Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold. Journal of Medicinal Chemistry, 2017, 60: 2697-2717.14. Li, Yi-Su; Guo, Bin-Bin; Xu, Zhi-Jian*; Li, Bo; Cai, Ting-Ting; Zhang, Xin-Ben; Yu, Yu-Qi; Wang, He-Yao*; Shi, Ji-Ye; Zhu, Wei-Liang*. Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay. Scientific Reports, 2016, 6: 31074.15. Sun, Peng; Wang, Ting; Chen, Lu; Yu, Bang-Wei; Jia, Qi; Chen, Kai-Xian; Fan, Hui-Min; Li, Yi-Ming*; Wang, He-Yao*. Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic beta-cells in vitro. Acta Pharmacologica Sinica, 2016, 37(8): 1083-1090.16. Yu, Bang-Wei; Li, Jin-Long; Guo, Bin-Bin; Fan, Hui-Min*; Zhao, Wei-Min*; Wang, He-Yao*. Chlorogenic acid analogues from Gynura nepalensis protect H9c2 cardiomyoblasts against H2O2-induced apoptosis. Acta Pharmacologica Sinica, 2016, 37(11): 1413-1422.17. Ji, Jun; Zhu, Jing-Jie; Hu, Xiao; Wang, Ting; Zhang, Xiao-Dong; Hou, Ai-Jun*; Wang, He-Yao* (2S)-7,4\'-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells. Biochemical and Biophysical Research Communications, 2015, 460(3): 578-582.18. Jiang, Tao; Zhou, Yu-Ren; Chen, Zhu-Xi; Sun, Peng; Zhu, Jian-Ming; Zhang, Qiang; Wang, Zhen; Shao, Qiang; Jiang, Xiang-Rui; Li, Bo; Chen, Kai-Xian; Jiang, Hua-Liang; Wang, He-Yao*; Zhu, Wei-Liang; Shen, Jing-Shan. Design, Synthesis, and Pharmacological Evaluation of Fused beta-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors. ACS Medicinal Chemistry Letters, 2015, 6(5): 602-606.19. Zhou, Yu-Ren; Sun, Peng; Wang, Ting; Chen, Kai-Xian; Zhu, Wei-Liang; Wang, He-Yao*. Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic beta-Cells via Regulation of Endoplasmic Reticulum Stress. PLos One, 2015, 10(7): e**-e**.20.Chen, Lu; Chen, Liang; Wang, Ting; Yuan Pu-Long; Chen, Kai-Xian; Jia, Qi; Wang He-Yao *; and Li, Yi-Ming *. Preparation of Methylated Products of A-type Procyanidin Trimersin Cinnam on Bark and Their Protective Effects on Pancreatic β-Cell. Journal of Food Science, 2016, 81(5): C1063-9.21. Zhu, Jing-Jie; Yan, Gui-Rui; Xu, Zhi-Jian; Hu, Xiao; Wang, Gai-Hong; Wang, Ting; Zhu, Wei-Liang; Hou, Ai-Jun; Wang, He-Yao*. Inhibitory Effects of (2\'R)-2\',3\'-dihydro-2\'- (1-hydroxy-1–methylethyl)-2,6\'-bibenzofuran-6,4\'-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells. Phytotherapy Research, 2015, 29(7): 1040-1045.22. Cai, Hai-Yan; Liu, Qiu-Feng; Gao, Ding-Ding; Wang, Ting; Chen, Tian-Tian; Yan, Gui-Rui; Chen, Kai-Xian; Xu, Ye-Chun*; Wang, He-Yao*; Li, Ying-Xia; Zhu, Wei-Liang*. Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. European Journal of Medicinal Chemistry, 2015, 90: 241-250.23. Ting Wang, Peng Sun, Liang Chen, Qi Huang, Kaixian Chen, Qi Jia, Yiming Li,* Heyao Wang*. Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. Journal of Agricultural and Food Chemistry, 2014, 62:5038-504524. Lin-Fu Liang, Ting Wang, You-Sheng Cai, Wen-Fei He, Peng Sun, Yu-Fen Li, Qi Huang, Orazio Taglialatela-Scafati*, He-Yao Wang*, Yue-Wei Guo*. Brominated polyunsaturated lipids from the Chinese sponge Xestospongia testudinaria as a new class of pancreatic lipase inhibitors. European Journal of Medicinal Chemistry. 2014, 79:290-29725. Jia Liu, Xiu-Feng He, Gai-Hong Wang, Emilio F. Merino, Sheng-Ping Yang,Rong-Xiu Zhu,Li-She Gan, Hua Zhang, Maria B. Cassera, He-Yao Wang, David G. I. Kingston, and Jian-Min Yue*. Aphadilactones A-D, Four Diterpenoid Dimers with DGAT Inhibitory and Antimalarial Activities from a Meliaceae Plant. The Journal of Organic Chemistry, 2014, 79:599-60726. Bo Li, Gaihong Wang, Zhijian Xu, Yong Zhang, Xiangui Huang, Bubing Zeng, Kaixian Chen, Jiye Shi*, Heyao Wang*, Weiliang Zhu*. Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement. European Journal of Medicinal Chemistry, 2014, 77:204-210
jyjl:河南医科大学医学系，医学学士学位
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