xm:贺金雪
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:jinxue_he@simm.ac.cn
grzy:
zjlb:
zw:
txdz:上海市浦东新区海科路501号
grjj:贺金雪，博士，中国科学院上海药物研究所研究员。2012年于中国科学院上海药物研究所获得博士学位，同年在美国康奈尔大学从事博士后研究，2016年回到上海药物研究所，先后任助理研究员、副研究员和研究员。主要从事抗肿瘤新药研发及作用机制研究。作为主要研究人员研发了1.1类新药盐酸美呋哌瑞和希明哌瑞，目前均处在I期临床。共发表学术论文20余篇，其中以第一或通信作者在Nat Commun、Cancer Lett.、Oncotarget等学术期刊发表9篇；相关研究成果获授权专利7项；入选上海市启明星计划、中科院青年创新促进会会员，并获SANOFI-SIBS优秀青年人才奖的资助。
yjfx:主要从事DNA损伤修复、泛素蛋白酶体途径的作用机制研究和创新药物发现。
dblz:(1) Hua-Dong Chen#, Ne Guo, Shan-Shan Song, Chuan-Huizi Chen, Ze-Hong Miao*, Jin-Xue He*. Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors. Am J Cancer Res. 2020 Sep 1; 10(9):2813-2831.

(2) Wang YT#, Yuan B, Chen HD, Xu L, Tian YN, Zhang A, He JX*, Miao ZH*. Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression. Cancer Sci. 2018 Mar; 109(3):821-831.

(3) Jin-Xue He#, Meng Wang# , Xia-Juan Huan, Chuan-Huizi Chen, Shan-Shan Song, et.al. Novel PARP1/2 Inhibitor Mefuparib Hydrochloride Elicits Potent In Vitro and In Vivo Anticancer Activity, Characteristic of High Tissue Distribution. Oncotarget. 2017 Jan17; 8(3):4156-4168.

(4) Bo Yuan#, Na Ye#, Shan-Shan Song, Yu-Ting Wang, Zilan Song, Hua-Dong Chen, Chuan-Huizi Chen, Xia-Juan Huan, Ying-Qing Wang, Yi Su, Yan-Yan Shen, Yi-Ming Sun, Xin-Yin Yang, Yi Chen, Shi-Yan Guo, Yong Gan, Zhi-Wei Gao, Xiao-Yan Chen, Jian Ding, Jin-Xue He*, Ao Zhang*, Ze-Hong Miao*. Poly(ADP-ribose)polymerase (PARP) Inhibition and Anticancer Activity of Simmiparib, a New Inhibitor Undergoing Clinical Trials. Cancer Lett. 2017 Feb 1; 386:47-56

(5) Zhong-Min Yang#, Xue-Mei Liao#, Chen Yi, Yi Chen, Yan-Yan Shen, Xin-Ying Yang, Yi Su, Yi-Ming Sun, Ying-Lei Gao, Jian Ding, Ao Zhang, Jin-Xue He*, Ze-Hong Miao*. Combination of 53BP1 With BRCA1 to Predict the Sensitivity of Poly(ADP-ribose) Polymerase (PARP) Inhibitors . Acta Pharmacol Sin. 2017 Jul; 38(7):1038-1047

(6) Jinxue He#, Zhong Zhang#, Meng Ouyang, Fan Yang, Hongbo Hao, Kristy L. Lamb, Jingyi Yang, Yuxin Yin*, Wen H. Shen*. PTEN regulates Eg5 to control spindle architecture and chromosome congression during mitosis. Nat Commun. 2016 Aug 5; 7:12355.

(7) Jinxue He#, Xi Kang, Yuxin Yin, K.S. Clifford Chao, Wen H. Shen*. PTEN regulates DNA replication progression and stalled fork recovery. Nat Commun. 2015 Jul 9; 6:7620

(8) Jin-Xue He#, Ying-Qing Wang#, Jian-Ming Feng, Jia-Xin Li, Lei Xu, Xiao-Hua Li, Xia-Juan Huan, Jian Ding, Ze-Hong Miao*. Differential sensitivity of RIP3-proficient and deficient murine fibroblasts to camptothecin anticancer drugs. Acta Pharmacol Sin. 2012; 33: 426-428.

(9) Jin-Xue He#, Chun-Hao Yang, Ze-Hong Miao*. PARP inhibitors as promising cancer therapeutics. Acta Pharmacol Sin. 2010;31:1172-1180.

jyjl:
gzjl:2012.9-2016.1美国康奈尔大学威尔医学院，博士后