王刚

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学　　位：
博士

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研究中心：
食品生物技术中心

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研究领域：
食品微生物学

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联系电话：

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手　　机：

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Email：
wanggang@jiangnan.edu.cn

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通讯地址：
江苏省无锡市蠡湖大道1800号

个人简介 ?个人简介
王刚，江南大学食品学院副教授、硕士生导师，中国科学院生物物理研究所生物化学与分子生物学专业博士学位，英国Norwich Research Park，Quadram Institute Bioscience高级访问****。主要从事食品微生物学、食品免疫学等方面的教学及研究工作。研究方向集中在功能性益生菌资源发掘、益生菌功能机制解析及益生菌产品开发。研究内容涵盖益生菌缓解代谢性疾病，益生菌缓解肠道疾病，益生菌缓解精神类疾病，益生菌拮抗食源性致病菌以及益生菌缓解食源性有毒化合物的毒害作用等方面的研究，尤其在益生菌对便秘、II型糖尿病及抑郁症等的缓解机制研究方面取得了较为突出的成果。
近年来主持并参与了省部级以上项目6项，并与诺维信、无限极、上海光明等国际、国内知名企业具有紧密的研发合作关系。申请发明专利100余项（其中包括国际发明专利13项），获授权发明专利37项（其中包括国际专利8项），发表论文40余篇（其中以第一作者或通讯作者发表SCI论文20余篇）。作为主要完成人的发明专利“一种具有排镉功能的植物乳杆菌及其用途”获得2015年第十七届中国专利金奖，“功能性益生乳酸菌的开发及产业化应用”获2014年中国商业联合会全国商业科技进步奖一等奖，“生物减除食源性危害的益生菌开发与应用”获2018年教育部高等学校科学研究优秀成果奖科学技术进步奖二等奖。




科研项目 1.短双歧杆菌CCFM1025对小鼠肠脑轴中5-羟色氨酸及5-羟色胺合成转运的影响及其机制：国家自然科学基金面上项目（**），主持，2020.01-2023.12
2.植物乳杆菌对全氟化合物毒害的缓解及作用机制：国家自然科学基金面上项目（**），主持，2017.01-2020.12





学术论文 1.Gang Wang, Qian Si, Shurong Yang, Ting Jiao, Huiyue Zhu, Peijun Tian, Linlin Wang, Xiu Li, Lei Gong*, Jianxin Zhao, Hao Zhang, Wei Chen*. Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manner.Food & Function, 2020, DOI: 10.1039/C9FO02761K
2.Yufeng He, Qianqian Wang, Xiu Li,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen. Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota.Food & Function, 2020, DOI: 10.1039/C9FO02554E
3.Gang Wang, Qian Liu, Zhangming Pei, Linlin Wang, Peijun Tian, Zhenmin Liu*, Jianxin Zhao, Hao Zhang, Wei Chen*. The diversity of the CRISPR-Cas system and Prophages present in the genome reveals the co-evolution ofBifidobacterium pseudocatenulatumand phages.Frontiers in Microbiology, 2020, DOI: 10.3389/fmicb.2020.01088
4.Peijun Tian, Kenneth J. O’Riordan, Yuan-kun Lee,Gang Wang*, Jianxin Zhao, Hao Zhang, John F. Cryan*, Wei Chen. Towards a psychobiotic therapy for depression:Bifidobacterium breveCCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice.Neurobiology of Stress, 2020, 12, 100216, DOI: 10.1016/j.ynstr.2020.100216
5.Gang Wang, Shanshan Sun, Xiaobing Wu, Shurong Yang, Yanmin Wu*, Jianxin Zhao*, Hao Zhang, Wei Chen. Intestinal environmental disorders associate with the tissue damages induced by perfluorooctane sulfonate exposure.Ecotoxicology and Environmental Safety, 2020, 197, 110590, DOI: 10.1016/j.ecoenv.2020.110590
6.Gang Wang, Qian Chen, Peijun Tian, Linlin Wang, Xiu Li, Yuan-kun Lee, Jianxin Zhao, Hao Zhang, Wei Chen*. Gut microbiota dysbiosis might be responsible to different toxicity caused by Di-(2-ethylhexyl) phthalate exposure in murine rodents.Environmental Pollution, 2020.02.14, DOI: 10.1016/j.envpol.2020.114164
7.Xing Jin, Yufeng He, Zhenmin Liu*, Yonghua Zhou*, Xiaohua Chen,Gang Wang*, Zhihong Sun, Jianxin Zhao, Hao Zhang, Wei Chen. Lactic acid bacteria exhibit similar antioxidant capacities inCaenorhabditis elegans- andCampylobacter jejuni-infected mice.RSC Advances, 2020, 10, 3329 – 3342
8.Gang Wang, Yunxia Yu, Enriqueta Garcia-Gutierrez, Xing Jin, Yufeng He, Linlin Wang, Peijun Tian, Zhenmin Liu*, Jianxin Zhao, Hao Zhang, Wei Chen*.Lactobacillus acidophilusJCM 1132 Strain and Its Mutant with Different Bacteriocin-Producing Behaviour Have Various In Situ Effects on the Gut Microbiota of Healthy Mice.Microorganisms, 2020, 8(1), 49; DOI: 10.3390/microorganisms**
9.Peijun Tian, Renying Zou, Linhong Song, Xu Zhang, Bin Jiang,Gang Wang*, Yuan-Kun Lee, Jianxin Zhao, Hao Zhang, Wei Chen. Ingestion ofBifidobacterium longumsubspeciesinfantisstrain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota.Food & Function, 2019,10(11), 7588-7598
10.Linlin Wang, Ceiling Chen, Shumao Cui, Yuan-kun Lee,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen. AdhesiveBifidobacteriumInduced Changes in Cecal Microbiome Alleviated Constipation in Mice.Frontiers in Microbiology, 2019, 10; DOI: 10.3389/fmicb.2019.01721
11.Peijun Tian,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen*.Bifidobacteriumwith the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis.Journal of Nutritional Biochemistry, 2019, 66:43-51
12.Gang Wang, Yufeng He, Xing Jin, Yonghua Zhou*, Xiaohua Chen, Jianxin Zhao, Hao Zhang, Wei Chen*. The Effect of Co-infection of Food-Borne Pathogenic Bacteria on the Progression ofCampylobacter jejuniInfection in Mice.Frontiers in microbiology, 2018, 9: 1977
13.Gang Wang, Qi Xu, Xing Jin, Feng Hang*, Zhenmin Liu, Jianxin Zhao*, Hao Zhang, Wei Chen. Effects of lactobacilli with different regulatory behaviours on tight junctions in mice with dextran sodium sulphate-induced colitis.Journal of Functional Foods, 2018,47(107-15)
14.Guangsu Zhu, Fangli Ma,Gang Wang*, Yuanyuan Wang*, Jianxin Zhao, Hao Zhang, Wei Chen. Bifidobacteria attenuate the development of metabolic disorders, with inter- and intra-species differences.Food & function, 2018,9(6):3509-22
15.Linlin Wang, Mingluo Pan, Dongyao Li, Yiting Yin, Tian Jiang, Shuguang Fang,Gang Wang*,Jianxin Zhao, Hao Zhang*, Wei Chen. Metagenomic insights into the effects of oligosaccharides on the microbial composition of cecal contents in constipated mice.Journal of Functional Foods, 2017, 38:486-496
16.Gang Wang*, Xiangfei Li, Jianxin Zhao*, Hao Zhang, Wei Chen.Lactobacillus caseiCCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism.Food & Function, 2017, 8(9):3155-3164
17.Xiangfei Li, Eryin Wang, Boxing Yin, Dongshen Fang, Pei Chen,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen. Effects ofLactobacillus caseiCCFM419 on insulin resistance and gut microbiota in type 2 diabetic mice.Beneficial Microbes, 2017, 8(3):421-432
18.Linlin Wang, Lujun Hu, Shuang Yan, Tian Jiang, Shuguang Fang,GangWang*, Jianxin Zhao, Hao Zhang, Wei Chen. Effects of different oligosaccharides at various dosages on the composition of gut microbiota and short-chain fatty acids in mice with constipation.Food & Function, 2017, 8(5):1966-1978
19.Linlin Wang, Lujun Hu, Qi Xu, Boxing Yin, Dongsheng Fang,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen.Bifidobacterium adolescentisExerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice.International Journal of Molecular Sciences, 2017, 18(2)
20.Linlin Wang, Lujun Hu, Qi Xu, Tian Jiang, Shuguang Fang,Gang Wang*, Jianxin Zhao, Hao Zhang*, Wei Chen. Bifidobacteria exert species-specific effects on constipation in BALB/c mice.Food & Function, 2017, 8(10):3587-3600
21.Qi Xu, Xiangfei Li, Eryin Wang, Yufeng He, Boxing Yin, Dongsheng Fang,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen. A cellular model for screening of lactobacilli that can enhance tight junctions.RSC Advances, 2016, 6: 111812-111821
22.Xiangfei Li, Na Wang, Boxing Yin, Dongsheng Fang, Jianxin Zhao, Hao Zhang,Gang Wang*, Wei Chen.Lactobacillus plantarumX1 with alpha-glucosidase Inhibitory Activity Ameliorates Type 2 Diabetes in Mice.RSC Advances, 2016, 6(68), 63536-63547
23.Xiangfei Li, Na Wang, Boxing Yin, Dongsheng Fang, Tian Jiang, Shuguang Fang, Jianxin Zhao, Hao Zhang,Gang Wang*, Wei Chen*. Effects ofLactobacillus plantarumCCFM0236 on Hyperglycemia and Insulin Resistance in High-fat and Streptozotocin Induced Type 2 Diabetic Mice.Journal of Applied Microbiology, 2016, 121(6): 1727-1736
24.Xiangfei Li, Na Wang, Qi Xu, Tian Jiang, Shuguang Fang,Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen*. A comparative study of the antidiabetic effects exerted by a live and dead multi-strain probiotic in the type 2 diabetes model of mice.Food & Function, 2016, 7(12): 4851-4860
25.Jiali Xing,Gang Wang*, Jichun Zhao, Eryin Wang, Boxing Yin, Dongsheng Fang, Jianxin Zhao, Hao Zhang, Yong Q. Chen, Wei Chen*. Toxicity assessment of perfluorooctane sulfonate using acute and subchronic male C57BL/6J mouse models.Environmental Pollution, 2016, 210: 388-396
26.Jiali Xing, Fan Wang, Qi Xu, Boxing Yin, Dongsheng Fang, Jianxin Zhao, Hao Zhang, Yong Q. Chen,Gang Wang*, Wei Chen. Screening of potential probiotic lactic acid bacteria based on gastrointestinal properties and perfluorooctanoate toxicity.Applied Microbiology and Biotechnology, 2016, 100(15): 6755-6766
27.Jiali Xing,Gang Wang*, Zhennan Gu, Xiaoming Liu, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Yong Q. Chen, Wei Chen*. Cellular model to assess the antioxidant activity of lactobacilli.RSC Advances, 2015, 5(47): 37626-37634
28.Jiali Xing,Gang Wang*, Qiuxiang Zhang, Xiaoming Liu, Zhennan Gu, Hao Zhang, Yong Q. Chen, Wei Chen*. Determining Antioxidant Activities of Lactobacilli Cell-Free Supernatants by Cellular Antioxidant Assay: A Comparison with Traditional Methods.PLOS One, 2015, 10(3):e**
29.Jiali Xing,Gang Wang*, Qiuxiang Zhang, Xiaoming Liu, Boxing Yin, Dongsheng Fang, Jianxin Zhao, Hao Zhang, Yong Q. Chen, Wei Chen*. Determining antioxidant Activities of lactobacilli by cellular antioxidant assay in mammal cells.Journal of Functional Foods, 2015, 19: 554-562
30.Gang Wang#, Jia Ning#, Jichun Zhao, Feng Hang, Fengwei Tian, Jianxin Zhao, Yongquan Chen, Hao Zhang, Wei Chen*. Partial characterisation of an anti-listeria substance produced byPediococcus acidilacticiP9.International Dairy Journal, 2014, 34(2): 275-279
31.Gang Wang, Yu Zhao, Fengwei Tian, Xing Jin, Haiqin Chen, Xiaoming Liu, Qiuxiang Zhang, Jianxin Zhao, Yongquan Chen, Hao Zhang, Wei Chen*. Screening of adhesive lactobacilli with antagonistic activity againstCampylobacter jejuni.Food Control, 2014, 44: 49-57
32.Lele Zhao #,Gang Wang #, Paul Siegel, Chuan He, Hezhong Wang, Wenjing Zhao, Zhengxiao Zhai, Fengwei Tian, Jianxin Zhao, Hao Zhang, Zikui Sun, Wei Chen *, Yan Zhang *, He Meng*. Quantitative genetic background of the host influences gut microbiomes in chickens.Scientific Reports, 2013, 3:1163





获奖 （1）2018年教育部高等学校科学研究优秀成果奖科学技术进步奖二等奖（第2完成人）：生物减除食源性危害的益生菌开发与应用
（2）2015年第十七届中国专利金奖（第4完成人）：一种具有排镉功能的植物乳杆菌及其用途
（3）2014年中国商业联合会科技进步奖一等奖（第2完成人）：功能性益生乳酸菌的开发及产业化应用





专利


承担教学


研究生培养

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