Prof. Wong Kwok-yin VP(EDU) & Chair Professor of Chemical Technology

Location M1707
Phone +852 3400 8686
mail kwok-yin.wong@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy, The University of Hong Kong
Bachelor of Science, The University of Hong Kong




Professional Qualifications Fellow of the Royal Society of Chemistry
Chartered Chemist




Research Overview We are interested in the development of inhibitors for bacterial proteins as antimicrobial agents, and the construction of biosensors to screen those inhibitors. Our group is also interested in new materials and catalysts for green chemistry and energy.




Academic and Professional Experiences Fellow of the Royal Society of Chemistry (UK)




Research Interests
Electrocatalysis and Photocatalysis
Biosensors
Green Chemistry
Antibiotic Development



Achievements

Awards
Patrick S.C. Poon Endowed Professorship (since 2013)
Natural Science Award (Second Class) by the Ministry of Education (2013)




Patents
Wong, K.Y.; Che, C.M.; Lu, W.; He, Z.K. 'Luminescent sensory material for organic-halogen compounds, and methods and apparatus utilizing such', U.S. Patent 6998271 (2006)
Wong, K.Y.; Leung, T.Y.C.; Chan, P.H. 'Modified beta-lactamases and uses thereof ', U.S. Patent 7323303 (2008).
Wong, K.Y.; Huang, C.; Kwok, C.S.; Snieckus, V. '16-Member ring metal chelate'. U.S. Patent 7557205 (2009).
Wong, K.Y.; Ma, D.L.; Wong, W.L.; Chung, W.H.; Chan, F.Y. 'Luminescent protein staining and method for detecting poly(amino acid) in a mixture'.U.S. Patent 2 (2009).
Wong, K.Y.; Leung, Y.C.; Chan, P.H.; Chung, W.H.; Chow, K.Y.; Chow, H.Y.; Leung, H.M. 'Method and system for detection of chloramphenicol'. U.S. Patent 2 (2012).
Wong, K.Y.; Chan, T.H.; Chan, K.F.; Chen, S.; Lui, H.K.; Kan, J.W.Y.; Chiou, J.C.; Yap, H.K. 'Preparation of 3-amino-benzamides as β-lactam auxiliary antibiotics', PCT Int. Appl.WO2016037573A120160317 (2016).
Wong, K.Y.; Chan, T.H.; Chan, K.F. Synthesis of pyrimidines for treatment of bacterial infections. PCT Int. Appl. WO 2017175045 (2017).




Representative Publications
Ha, E.; Lee, L.Y.S.; Wang, J.; Li, F.; Wong, K.Y.; Tsang, S.C.E. Significant Enhancement in Photocatalytic Reduction of Water to Hydrogen by Au/Cu2ZnSnS4 Advanced Materials, 2014, 26 (21), 3496-3500.
Chiou, J.; Wan, S.; Chan, K.F.; So, P.K.; He, D.; Chan, E.W.C.; Chan, T.H.; Wong, K.Y.; Jiang, T.; Chen, S. Ebselen as a potent covalent inhibitor for New Delhi Metallo-β-lactamase (NDM-1). Chemical Communications, 2015, 51(46), 9543-9546.
Xin, D.; Yuan, J.; Wong, K.Y.; Burgess, K. Heterogeneous phase transfer catalysis in solid phase synthesis of Anth-cyclic tetrapeptides. Journal of Organic Chemistry, 2016, 81 (17), 8077-8081.
Sun, N.; Du, R.L.; Zheng, Y.Y.; Huang, B.H.; Guo, Q.; Zhang, R.F.; Wong, K.Y.; Lu, Y.J. Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. European Journal of Medicinal Chemistry, 2017, 135, 1-11.
Zhu, Jing; Ha, Enna; Zhao, Guoliang; Zhou, Yang; Huang, Deshun; Yue, Guozong; Hu, Liangsheng; Sun, Ning; Wang, Yong; Lee, Lawrence Yoon Suk; Xu, Chen; Wong, Kwok-Yin; Astruc, Didier; Zhao, Pengxiang. Recent advance in MXenes: A promising 2D material for catalysis, sensor and chemical adsorption. Coordination Chemistry Reviews, 2017, 352, 306-327.
Wang, G.; Feng, H.; Hu, L.; Jin, W.; Hao, Q.; Gao, A.; Peng, X.; Li, W.; Wong, K.Y.; Wang, H.; Li, Z.; Chu, P. An Antibacterial Platform Based on Capacitive Carbon-Doped TiO2 Nanotubes after Charging with Direct/Alternating Currents". Nature Communications, 2018, 9:2055.
Zheng, G.; Bao, Z.; Pérez-Juste, J.; Du, R.; Liu, W.; Dai, J.; Zhang, W.; Lee, L.Y.S.; Wong, K.Y. Tuning the morphology and chiroptical properties of discrete gold nanorods with amino acids. Angewandte Chemie International Edition, 2018, 57, 16452-16457.
Li, Y.; Peng, Y.K.; Hu, L.; Zheng, J.; Prabhakaran, D.; Wu, S.; Puchtler, T. J.; Li, M; Wong, K.Y.; Taylor, R. A.; Tsang, S.C.E. Photocatalytic water splitting by N-TiO2 on MgO (111) with exceptional quantum efficiencies at elevated temperatures. Nature Communications, 2019, 10(1), 1-9.
Zhu, J.; Hu, L.; Zhao, P.; Lee, L. Y. S.; Wong, K.Y. Recent Advances in Electrocatalytic Hydrogen Evolution Using Nanoparticles. Chemical Reviews, 2020, 120 (2), 851-918.
Yu, R.; Wang, J.; So, L.Y.; Harvey, P. J.; Shi, J.; Liang, J.; Dou, Q.; Li, X.; Yan, X.; Huang, Y.H.; Xu, Q.; Kaas, Q.; Chow, H.Y.; Wong, K.Y.; Craik, D. J.; Zhang, X.H.; Jiang, T.; Wang, Y. Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. Journal of Medicinal Chemistry, 2020, 63(7), 3475-3484.




Book Chapters
Chen, X.; Xiao, L.R.; Yang, X.Q.; Zhao, L.; Wang, X.R.; Wong, K.Y. 'Biological Oxygen Demand Sensors' in Encyclopedia of Sensors, Grimes, C.A.; Dickey, E.C.; Pishko, M.V. ed., American Scientific Publishers, Valencia, California, 2006, vol. 1, pp. 313-328.
Lee, L.Y.S. and Wong, K.Y. 'Recent Development in Water Oxidation Catalysts Based on Manganese and Cobalt Complexes' in Organometallic and Related Molecules for Energy Conversion, Wong, W.Y. ed., Green Chemistry and Sustainable Technology Series, Springer, Berlin, 2015, chapter 13, pp.365-394.